Endoreduplication of the mouse genome in the absence of ORC1

The largest subunit of the origin recognition complex (ORC1) is essential for assembly of the prereplicative complex, firing of DNA replication origins, and faithful duplication of the genome. Here, we generated knock-in mice with LoxP sites flanking exons encoding the critical ATPase domain of ORC1...

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Detalles Bibliográficos
Autores principales: Okano-Uchida, Takayuki, Kent, Lindsey N., Ouseph, Madhu M., McCarty, Britney, Frank, Jeffrey J., Kladney, Raleigh, Cuitino, Maria C., Thompson, John C., Coppola, Vincenzo, Asano, Maki, Leone, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075035/
https://www.ncbi.nlm.nih.gov/pubmed/29967292
http://dx.doi.org/10.1101/gad.311910.118

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