Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and results in up-regulation of Igf2 in nephron progenitor cells

Loss of function of the DIS3L2 exoribonuclease is associated with Wilms tumor and the Perlman congenital overgrowth syndrome. LIN28, a Wilms tumor oncoprotein, triggers the DIS3L2-mediated degradation of the precursor of let-7, a microRNA that inhibits Wilms tumor development. These observations hav...

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Detalles Bibliográficos
Autores principales: Hunter, Ryan W., Liu, Yangjian, Manjunath, Hema, Acharya, Asha, Jones, Benjamin T., Zhang, He, Chen, Beibei, Ramalingam, Harini, Hammer, Robert E., Xie, Yang, Richardson, James A., Rakheja, Dinesh, Carroll, Thomas J., Mendell, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075040/
https://www.ncbi.nlm.nih.gov/pubmed/29950491
http://dx.doi.org/10.1101/gad.315804.118

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