Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1

Many childhood Wilms tumors are driven by mutations in the microRNA biogenesis machinery, but the mechanism by which these mutations drive tumorigenesis is unknown. Here we show that the transcription factor pleomorphic adenoma gene 1 (PLAG1) is a microRNA target gene that is overexpressed in Wilms...

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Detalles Bibliográficos
Autores principales: Chen, Kenneth S., Stroup, Emily K., Budhipramono, Albert, Rakheja, Dinesh, Nichols-Vinueza, Diana, Xu, Lin, Stuart, Sarai H., Shukla, Abhay A., Fraire, Claudette, Mendell, Joshua T., Amatruda, James F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075147/
https://www.ncbi.nlm.nih.gov/pubmed/30026293
http://dx.doi.org/10.1101/gad.313783.118

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