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The LIN28B–IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine

RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we describe a novel interplay between RBPs LIN28B and IMP1...

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Detalles Bibliográficos
Autores principales: Chatterji, Priya, Hamilton, Kathryn E., Liang, Shun, Andres, Sarah F., Wijeratne, H.R. Sagara, Mizuno, Rei, Simon, Lauren A., Hicks, Philip D., Foley, Shawn W., Pitarresi, Jason R., Klein-Szanto, Andres J., Mah, Amanda T., Van Landeghem, Laurianne, Gregory, Brian D., Lengner, Christopher J., Madison, Blair B., Shah, Premal, Rustgi, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075153/
https://www.ncbi.nlm.nih.gov/pubmed/30068703
http://dx.doi.org/10.1101/gad.314369.118