Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

DNA methylation (DNAm)-based biomarkers of aging have been developed for many tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts and other cell types used in ex vivo studies. To address this challenge, we developed a novel and highly robust DNAm age estimator (bas...

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Detalles Bibliográficos
Autores principales: Horvath, Steve, Oshima, Junko, Martin, George M., Lu, Ake T., Quach, Austin, Cohen, Howard, Felton, Sarah, Matsuyama, Mieko, Lowe, Donna, Kabacik, Sylwia, Wilson, James G., Reiner, Alex P., Maierhofer, Anna, Flunkert, Julia, Aviv, Abraham, Hou, Lifang, Baccarelli, Andrea A., Li, Yun, Stewart, James D., Whitsel, Eric A., Ferrucci, Luigi, Matsuyama, Shigemi, Raj, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075434/
https://www.ncbi.nlm.nih.gov/pubmed/30048243
http://dx.doi.org/10.18632/aging.101508

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