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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, a...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075733/ https://www.ncbi.nlm.nih.gov/pubmed/29617669 http://dx.doi.org/10.1016/j.celrep.2018.03.075 |
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| author | Ricketts, Christopher J. De Cubas, Aguirre A. Fan, Huihui Smith, Christof C. Lang, Martin Reznik, Ed Bowlby, Reanne Gibb, Ewan A. Akbani, Rehan Beroukhim, Rameen Bottaro, Donald P. Choueiri, Toni K. Gibbs, Richard A. Godwin, Andrew K. Haake, Scott Hakimi, A. Ari Henske, Elizabeth P. Hsieh, James J. Ho, Thai H. Kanchi, Rupa S. Krishnan, Bhavani Kwaitkowski, David J. Lui, Wembin Merino, Maria J. Mills, Gordon B. Myers, Jerome Nickerson, Michael L. Reuter, Victor E. Schmidt, Laura S. Shelley, C. Simon Shen, Hui Shuch, Brian Signoretti, Sabina Srinivasan, Ramaprasad Tamboli, Pheroze Thomas, George Vincent, Benjamin G. Vocke, Cathy D. Wheeler, David A. Yang, Lixing Kim, William T. Robertson, A. Gordon Spellman, Paul T. Rathmell, W. Kimryn Linehan, W. Marston |
| author_facet | Ricketts, Christopher J. De Cubas, Aguirre A. Fan, Huihui Smith, Christof C. Lang, Martin Reznik, Ed Bowlby, Reanne Gibb, Ewan A. Akbani, Rehan Beroukhim, Rameen Bottaro, Donald P. Choueiri, Toni K. Gibbs, Richard A. Godwin, Andrew K. Haake, Scott Hakimi, A. Ari Henske, Elizabeth P. Hsieh, James J. Ho, Thai H. Kanchi, Rupa S. Krishnan, Bhavani Kwaitkowski, David J. Lui, Wembin Merino, Maria J. Mills, Gordon B. Myers, Jerome Nickerson, Michael L. Reuter, Victor E. Schmidt, Laura S. Shelley, C. Simon Shen, Hui Shuch, Brian Signoretti, Sabina Srinivasan, Ramaprasad Tamboli, Pheroze Thomas, George Vincent, Benjamin G. Vocke, Cathy D. Wheeler, David A. Yang, Lixing Kim, William T. Robertson, A. Gordon Spellman, Paul T. Rathmell, W. Kimryn Linehan, W. Marston |
| author_sort | Ricketts, Christopher J. |
| collection | PubMed |
| description | Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival. |
| format | Online Article Text |
| id | pubmed-6075733 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-60757332018-08-03 The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma Ricketts, Christopher J. De Cubas, Aguirre A. Fan, Huihui Smith, Christof C. Lang, Martin Reznik, Ed Bowlby, Reanne Gibb, Ewan A. Akbani, Rehan Beroukhim, Rameen Bottaro, Donald P. Choueiri, Toni K. Gibbs, Richard A. Godwin, Andrew K. Haake, Scott Hakimi, A. Ari Henske, Elizabeth P. Hsieh, James J. Ho, Thai H. Kanchi, Rupa S. Krishnan, Bhavani Kwaitkowski, David J. Lui, Wembin Merino, Maria J. Mills, Gordon B. Myers, Jerome Nickerson, Michael L. Reuter, Victor E. Schmidt, Laura S. Shelley, C. Simon Shen, Hui Shuch, Brian Signoretti, Sabina Srinivasan, Ramaprasad Tamboli, Pheroze Thomas, George Vincent, Benjamin G. Vocke, Cathy D. Wheeler, David A. Yang, Lixing Kim, William T. Robertson, A. Gordon Spellman, Paul T. Rathmell, W. Kimryn Linehan, W. Marston Cell Rep Article Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival. 2018-04-03 /pmc/articles/PMC6075733/ /pubmed/29617669 http://dx.doi.org/10.1016/j.celrep.2018.03.075 Text en This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Ricketts, Christopher J. De Cubas, Aguirre A. Fan, Huihui Smith, Christof C. Lang, Martin Reznik, Ed Bowlby, Reanne Gibb, Ewan A. Akbani, Rehan Beroukhim, Rameen Bottaro, Donald P. Choueiri, Toni K. Gibbs, Richard A. Godwin, Andrew K. Haake, Scott Hakimi, A. Ari Henske, Elizabeth P. Hsieh, James J. Ho, Thai H. Kanchi, Rupa S. Krishnan, Bhavani Kwaitkowski, David J. Lui, Wembin Merino, Maria J. Mills, Gordon B. Myers, Jerome Nickerson, Michael L. Reuter, Victor E. Schmidt, Laura S. Shelley, C. Simon Shen, Hui Shuch, Brian Signoretti, Sabina Srinivasan, Ramaprasad Tamboli, Pheroze Thomas, George Vincent, Benjamin G. Vocke, Cathy D. Wheeler, David A. Yang, Lixing Kim, William T. Robertson, A. Gordon Spellman, Paul T. Rathmell, W. Kimryn Linehan, W. Marston The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma |
| title | The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma |
| title_full | The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma |
| title_fullStr | The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma |
| title_full_unstemmed | The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma |
| title_short | The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma |
| title_sort | cancer genome atlas comprehensive molecular characterization of renal cell carcinoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075733/ https://www.ncbi.nlm.nih.gov/pubmed/29617669 http://dx.doi.org/10.1016/j.celrep.2018.03.075 |
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