Clinical characteristics and prognostic factors of pneumonia in patients with and without rheumatoid arthritis

BACKGROUND: To elucidate the characteristics of pneumonia in rheumatoid arthritis (RA) patients and to assess whether pneumonia in RA patients differs from that in non-RA patients. METHODS: We retrospectively divided pneumonia patients into two groups, those with RA and those without RA, and compare...

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Autores principales: Wakabayashi, Aya, Ishiguro, Takashi, Takaku, Yotaro, Miyahara, Yosuke, Kagiyama, Naho, Takayanagi, Noboru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075779/
https://www.ncbi.nlm.nih.gov/pubmed/30075013
http://dx.doi.org/10.1371/journal.pone.0201799
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author Wakabayashi, Aya
Ishiguro, Takashi
Takaku, Yotaro
Miyahara, Yosuke
Kagiyama, Naho
Takayanagi, Noboru
author_facet Wakabayashi, Aya
Ishiguro, Takashi
Takaku, Yotaro
Miyahara, Yosuke
Kagiyama, Naho
Takayanagi, Noboru
author_sort Wakabayashi, Aya
collection PubMed
description BACKGROUND: To elucidate the characteristics of pneumonia in rheumatoid arthritis (RA) patients and to assess whether pneumonia in RA patients differs from that in non-RA patients. METHODS: We retrospectively divided pneumonia patients into two groups, those with RA and those without RA, and compared the two groups. We evaluated the risk factors for mortality with univariate and multivariate logistic regression analysis. RESULTS: Among 1549 patients, 71 had RA. The RA patients with pneumonia were 71.0±8.9 years old, 54.9% were female, 40.9% had a smoking history, and 71.8% had underlying respiratory disease. Female sex, non-smoker, and respiratory comorbidities were statistically more frequent in the RA patients than non-RA patients. The most frequent causative microbial agents of pneumonia in the RA patients were Streptococcus pneumoniae, Pseudomonas aeruginosa, Haemophilus influenzae, Mycoplasma pneumoniae, and influenza virus, whereas those of pneumonia in non-RA patients were S. pneumoniae, influenza virus, M. pneumoniae, Legionella spp., P. aeruginosa, H. influenzae, and Moraxella catarrhalis. Polymicrobial infection were identified as etiologies more frequently in the RA patients than non-RA patients. Although the severity of pneumonia did not differ between the two groups, mortality was statistically higher in the RA patients than non-RA patients. Multivariate analysis showed RA to be an independent risk factor for mortality. CONCLUSIONS: P. aeruginosa, H. influenzae, M. catarrhalis, and polymicrobial infection were statistically more frequent etiologies of pneumonia in the RA patients than non-RA patients. RA itself was found to be an independent risk factor for mortality from pneumonia.
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spelling pubmed-60757792018-08-28 Clinical characteristics and prognostic factors of pneumonia in patients with and without rheumatoid arthritis Wakabayashi, Aya Ishiguro, Takashi Takaku, Yotaro Miyahara, Yosuke Kagiyama, Naho Takayanagi, Noboru PLoS One Research Article BACKGROUND: To elucidate the characteristics of pneumonia in rheumatoid arthritis (RA) patients and to assess whether pneumonia in RA patients differs from that in non-RA patients. METHODS: We retrospectively divided pneumonia patients into two groups, those with RA and those without RA, and compared the two groups. We evaluated the risk factors for mortality with univariate and multivariate logistic regression analysis. RESULTS: Among 1549 patients, 71 had RA. The RA patients with pneumonia were 71.0±8.9 years old, 54.9% were female, 40.9% had a smoking history, and 71.8% had underlying respiratory disease. Female sex, non-smoker, and respiratory comorbidities were statistically more frequent in the RA patients than non-RA patients. The most frequent causative microbial agents of pneumonia in the RA patients were Streptococcus pneumoniae, Pseudomonas aeruginosa, Haemophilus influenzae, Mycoplasma pneumoniae, and influenza virus, whereas those of pneumonia in non-RA patients were S. pneumoniae, influenza virus, M. pneumoniae, Legionella spp., P. aeruginosa, H. influenzae, and Moraxella catarrhalis. Polymicrobial infection were identified as etiologies more frequently in the RA patients than non-RA patients. Although the severity of pneumonia did not differ between the two groups, mortality was statistically higher in the RA patients than non-RA patients. Multivariate analysis showed RA to be an independent risk factor for mortality. CONCLUSIONS: P. aeruginosa, H. influenzae, M. catarrhalis, and polymicrobial infection were statistically more frequent etiologies of pneumonia in the RA patients than non-RA patients. RA itself was found to be an independent risk factor for mortality from pneumonia. Public Library of Science 2018-08-03 /pmc/articles/PMC6075779/ /pubmed/30075013 http://dx.doi.org/10.1371/journal.pone.0201799 Text en © 2018 Wakabayashi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Wakabayashi, Aya
Ishiguro, Takashi
Takaku, Yotaro
Miyahara, Yosuke
Kagiyama, Naho
Takayanagi, Noboru
Clinical characteristics and prognostic factors of pneumonia in patients with and without rheumatoid arthritis
title Clinical characteristics and prognostic factors of pneumonia in patients with and without rheumatoid arthritis
title_full Clinical characteristics and prognostic factors of pneumonia in patients with and without rheumatoid arthritis
title_fullStr Clinical characteristics and prognostic factors of pneumonia in patients with and without rheumatoid arthritis
title_full_unstemmed Clinical characteristics and prognostic factors of pneumonia in patients with and without rheumatoid arthritis
title_short Clinical characteristics and prognostic factors of pneumonia in patients with and without rheumatoid arthritis
title_sort clinical characteristics and prognostic factors of pneumonia in patients with and without rheumatoid arthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075779/
https://www.ncbi.nlm.nih.gov/pubmed/30075013
http://dx.doi.org/10.1371/journal.pone.0201799
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