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Presenilin mutations deregulate mitochondrial Ca(2+) homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans

Mitochondrial dysfunction and subsequent metabolic deregulation is observed in neurodegenerative diseases and aging. Mutations in the presenilin (PSEN) encoding genes (PSEN1 and PSEN2) cause most cases of familial Alzheimer’s disease (AD); however, the underlying mechanism of pathogenesis remains un...

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Detalles Bibliográficos
Autores principales: Sarasija, Shaarika, Laboy, Jocelyn T, Ashkavand, Zahra, Bonner, Jennifer, Tang, Yi, Norman, Kenneth R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075864/
https://www.ncbi.nlm.nih.gov/pubmed/29989545
http://dx.doi.org/10.7554/eLife.33052
Descripción
Sumario:Mitochondrial dysfunction and subsequent metabolic deregulation is observed in neurodegenerative diseases and aging. Mutations in the presenilin (PSEN) encoding genes (PSEN1 and PSEN2) cause most cases of familial Alzheimer’s disease (AD); however, the underlying mechanism of pathogenesis remains unclear. Here, we show that mutations in the C. elegans gene encoding a PSEN homolog, sel-12 result in mitochondrial metabolic defects that promote neurodegeneration as a result of oxidative stress. In sel-12 mutants, elevated endoplasmic reticulum (ER)-mitochondrial Ca(2+) signaling leads to an increase in mitochondrial Ca(2+) content which stimulates mitochondrial respiration resulting in an increase in mitochondrial superoxide production. By reducing ER Ca(2+) release, mitochondrial Ca(2+) uptake or mitochondrial superoxides in sel-12 mutants, we demonstrate rescue of the mitochondrial metabolic defects and prevent neurodegeneration. These data suggest that mutations in PSEN alter mitochondrial metabolic function via ER to mitochondrial Ca(2+) signaling and provide insight for alternative targets for treating neurodegenerative diseases.