Presenilin mutations deregulate mitochondrial Ca(2+) homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans

Mitochondrial dysfunction and subsequent metabolic deregulation is observed in neurodegenerative diseases and aging. Mutations in the presenilin (PSEN) encoding genes (PSEN1 and PSEN2) cause most cases of familial Alzheimer’s disease (AD); however, the underlying mechanism of pathogenesis remains un...

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Detalles Bibliográficos
Autores principales: Sarasija, Shaarika, Laboy, Jocelyn T, Ashkavand, Zahra, Bonner, Jennifer, Tang, Yi, Norman, Kenneth R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075864/
https://www.ncbi.nlm.nih.gov/pubmed/29989545
http://dx.doi.org/10.7554/eLife.33052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075864/
https://www.ncbi.nlm.nih.gov/pubmed/29989545
http://dx.doi.org/10.7554/eLife.33052

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