Cargando…

Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses

Neurons communicate through neurotransmitter release at specialized synaptic regions known as active zones (AZs). Using biosensors to visualize single synaptic vesicle fusion events at Drosophila neuromuscular junctions, we analyzed the developmental and molecular determinants of release probability...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akbergenova, Yulia, Cunningham, Karen L, Zhang, Yao V, Weiss, Shirley, Littleton, J Troy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075867/ https://www.ncbi.nlm.nih.gov/pubmed/29989549 http://dx.doi.org/10.7554/eLife.38268

Ejemplares similares

Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development
por: Guss, Ellen J, et al.
Publicado: (2023)

Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner
por: Guan, Zhuo, et al.
Publicado: (2020)

The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity
por: Sauvola, Chad W, et al.
Publicado: (2021)

Molecular Logic of Synaptic Diversity Between Drosophila Tonic and Phasic Motoneurons
por: Jetti, Suresh K., et al.
Publicado: (2023)

Synaptic Plasticity Induced by Differential Manipulation of Tonic and Phasic Motoneurons in Drosophila
por: Aponte-Santiago, Nicole A., et al.
Publicado: (2020)

A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca(2+) cooperativity of vesicle fusion
por: Guan, Zhuo, et al.
Publicado: (2017)

Function of Drosophila Synaptotagmins in membrane trafficking at synapses
por: Quiñones-Frías, Mónica C., et al.
Publicado: (2021)

Characterization of axonal transport defects in Drosophila Huntingtin mutants
por: Weiss, Kurt R., et al.
Publicado: (2016)

A Genomic Analysis of Membrane Trafficking and Neurotransmitter Release in Drosophila
por: Littleton, J. Troy
Publicado: (2000)

Spatiotemporal dynamics of multi-vesicular release is determined by heterogeneity of release sites within central synapses
por: Maschi, Dario, et al.
Publicado: (2020)

The Synapse Diversity Dilemma: Molecular Heterogeneity Confounds Studies of Synapse Function
por: Grant, Seth G. N., et al.
Publicado: (2020)

Mechanisms controlling the trafficking, localization, and abundance of presynaptic Ca(2+) channels
por: Cunningham, Karen L., et al.
Publicado: (2023)

Regulation of presynaptic Ca(2+) channel abundance at active zones through a balance of delivery and turnover
por: Cunningham, Karen L, et al.
Publicado: (2022)

Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila
por: Pribbenow, Carlotta, et al.
Publicado: (2022)

A presynaptic endosomal trafficking pathway controls synaptic growth signaling
por: Rodal, Avital A., et al.
Publicado: (2011)

Characterization of a hypercontraction-induced myopathy in Drosophila caused by mutations in Mhc
por: Montana, Enrico S., et al.
Publicado: (2004)

Cellular Mechanisms Contributing to the Functional Heterogeneity of GABAergic Synapses
por: Campbell, Benjamin F. N., et al.
Publicado: (2019)

Maturation of Heterogeneity in Afferent Synapse Ultrastructure in the Mouse Cochlea
por: Payne, Shelby A., et al.
Publicado: (2021)

A Phenomenological Synapse Model for Asynchronous Neurotransmitter Release
por: Wang, Tao, et al.
Publicado: (2016)

Probing Single Synapses via the Photolytic Release of Neurotransmitters
por: Mitchell, Diana E., et al.
Publicado: (2019)

Synaptic Release Potentiation at Aging Auditory Ribbon Synapses
por: Peineau, Thibault, et al.
Publicado: (2021)

Developmental Shift of Inhibitory Transmitter Content at a Central Auditory Synapse
por: Nerlich, Jana, et al.
Publicado: (2017)

Super Resolution Imaging of Genetically Labeled Synapses in Drosophila Brain Tissue
por: Spühler, Isabelle A., et al.
Publicado: (2016)

Imaging neuropeptide release at synapses with a genetically engineered reporter
por: Ding, Keke, et al.
Publicado: (2019)

Calcium dependence of neurotransmitter release at a high fidelity synapse
por: Eshra, Abdelmoneim, et al.
Publicado: (2021)

The Drosophila KIF1A Homolog unc-104 Is Important for Site-Specific Synapse Maturation
por: Zhang, Yao V., et al.
Publicado: (2016)

An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum
por: Lai, Esther Suk King, et al.
Publicado: (2021)

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses
por: Fanutza, Tomas, et al.
Publicado: (2015)

Synapse Maturation and Developmental Impairment in the Medial Nucleus of the Trapezoid Body
por: Chokr, Sima M., et al.
Publicado: (2022)

Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses
por: Romani, Armando, et al.
Publicado: (2013)

Correction: Imaging neuropeptide release at synapses with a genetically engineered reporter
por: Ding, Keke, et al.
Publicado: (2019)

Synaptic vesicle release during ribbon synapse formation of cone photoreceptors
por: Davison, Adam, et al.
Publicado: (2022)

Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses
por: Malagon, Gerardo, et al.
Publicado: (2023)

Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses
por: Karagulyan, Nare, et al.
Publicado: (2023)

SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling
por: Sauvola, Chad W., et al.
Publicado: (2021)

Neurons regulate synaptic strength through homeostatic scaling of active zones
por: Cunningham, Karen L., et al.
Publicado: (2019)

Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP(3)-directed signaling
por: James, Thomas D, et al.
Publicado: (2019)

Early Draper-mediated glial refinement of neuropil architecture and synapse number in the Drosophila antennal lobe
por: Jindal, Darren A., et al.
Publicado: (2023)

NMDAR-Mediated Calcium Transients Elicited by Glutamate Co-Release at Developing Inhibitory Synapses
por: Kalmbach, Abigail, et al.
Publicado: (2010)

Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse
por: Tagliatti, Erica, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jgqkferp83ceuuei4npdeouhjc