Evaluation of drug effects on cerebral blood flow and glucose uptake in un-anesthetized and un-stimulated rats: application of free-moving apparatus enabling to keep rats free during PET/SPECT tracer injection and uptake

OBJECTIVES: The purpose of this study is the development of novel fluorine-18-fluorodeoxyglucose ((18)F-FDG)-PET and (99m)Tc-hexamethylpropylene amine oxime (HMPAO) SPECT methods with free-moving apparatus on conscious rats to investigate brain activity without the effects of anesthesia and tactual...

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Detalles Bibliográficos
Autores principales: Sugita, Taku, Kondo, Yusuke, Ishino, Seigo, Mori, Ikuo, Horiguchi, Takashi, Ogawa, Mikako, Magata, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075887/
https://www.ncbi.nlm.nih.gov/pubmed/29771718
http://dx.doi.org/10.1097/MNM.0000000000000863

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