Cargando…

Low expression of aging-related NRXN3 is associated with Alzheimer disease: A systematic review and meta-analysis

BACKGROUND: Alzheimer disease (AD) is a common neurodegenerative disorder with distinct pathological features, with aging considered the greatest risk factor. We explored how aging contributes to increased AD risk, and determined concurrent and coordinate changes (including genetic and phenotypic mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Jun-Juan, Li, Wen-Xing, Liu, Jia-Qian, Guo, Yi-Cheng, Wang, Qian, Li, Gong-Hua, Dai, Shao-Xing, Huang, Jing-Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076205/ https://www.ncbi.nlm.nih.gov/pubmed/29995770 http://dx.doi.org/10.1097/MD.0000000000011343

Ejemplares similares

Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets
por: Li, Wen-Xing, et al.
Publicado: (2016)

A strategy to find novel candidate anti-Alzheimer’s disease drugs by constructing interaction networks between drug targets and natural compounds in medical plants
por: Chen, Bi-Wen, et al.
Publicado: (2018)

The identification and molecular mechanism of anti-stroke traditional Chinese medicinal compounds
por: Liu, Jia-Qian, et al.
Publicado: (2017)

Mutations in NRXN1 and NRXN2 in a patient with early-onset epileptic encephalopathy and respiratory depression
por: Rochtus, Anne M., et al.
Publicado: (2019)

Identification of metabolism-associated genes and pathways involved in different stages of clear cell renal cell carcinoma
por: Li, Hui-Juan, et al.
Publicado: (2018)

In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database
por: Dai, Shao-Xing, et al.
Publicado: (2016)

Corrigendum: In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database
por: Dai, Shao-Xing, et al.
Publicado: (2016)

miR-196a-2 Promotes Malignant Progression of Thyroid Carcinoma by Targeting NRXN1
por: Fan, Yaohua, et al.
Publicado: (2021)

Precise Therapeutic Targeting of Distinct NRXN1(+/−) Mutations
por: Fernando, Michael B., et al.
Publicado: (2023)

Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency
por: Li, Wen-Xing, et al.
Publicado: (2015)

Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3
por: Liu, Liang, et al.
Publicado: (2021)

NRXN1 deletions identified by array comparative genome hybridisation in a clinical case series – further understanding of the relevance of NRXN1 to neurodevelopmental disorders
por: Curran, Sarah, et al.
Publicado: (2013)

Independent Evolution of Winner Traits without Whole Genome Duplication in Dekkera Yeasts
por: Guo, Yi-Cheng, et al.
Publicado: (2016)

Mutation Analysis of the NRXN1 Gene in Autism Spectrum Disorders
por: Onay, H, et al.
Publicado: (2016)

Neurexin 1 (NRXN1) Splice Isoform Expression During Human Neocortical Development and Aging
por: Jenkins, Aaron K., et al.
Publicado: (2015)

Neuronal impact of patient-specific aberrant NRXN1α splicing
por: Flaherty, Erin, et al.
Publicado: (2019)

Gain and loss events in the evolution of the apolipoprotein family in vertebrata
por: Liu, Jia-Qian, et al.
Publicado: (2019)

FoxQ1 Promotes Glioma Cells Proliferation and Migration by Regulating NRXN3 Expression
por: Sun, Hong-Tao, et al.
Publicado: (2013)

Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1
por: Gregor, Anne, et al.
Publicado: (2011)

Functional Impacts of NRXN1 Knockdown on Neurodevelopment in Stem Cell Models
por: Zeng, Liyun, et al.
Publicado: (2013)

NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis
por: Alliey-Rodriguez, Ney, et al.
Publicado: (2019)

Identification of hub ubiquitin ligase genes affecting Alzheimer’s disease by analyzing transcriptome data from multiple brain regions
por: Liu, Dahai, et al.
Publicado: (2021)

ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin‐3 and NRXN3
por: Zhao, Yin, et al.
Publicado: (2020)

Proteome-wide prediction of targets for aspirin: new insight into the molecular mechanism of aspirin
por: Dai, Shao-Xing, et al.
Publicado: (2016)

A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population
por: Yue, Weihua, et al.
Publicado: (2011)

A common cognitive, psychiatric, and dysmorphic phenotype in carriers of NRXN1 deletion
por: Viñas-Jornet, Marina, et al.
Publicado: (2014)

Allelic contribution of Nrxn1α to autism-relevant behavioral phenotypes in mice
por: Xu, Bing, et al.
Publicado: (2023)

NRXN1α(+/-) is associated with increased excitability in ASD iPSC-derived neurons
por: Avazzadeh, Sahar, et al.
Publicado: (2021)

Deletions of NRXN1 (Neurexin-1) Predispose to a Wide Spectrum of Developmental Disorders
por: Ching, Michael SL, et al.
Publicado: (2010)

Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia
por: Ishizuka, Kanako, et al.
Publicado: (2020)

Deletion of NRXN1α impairs long-range and local connectivity in amygdala fear circuit
por: Asede, Douglas, et al.
Publicado: (2020)

Disruption of Nrxn1α within excitatory forebrain circuits drives value-based dysfunction
por: Alabi, Opeyemi O, et al.
Publicado: (2020)

Is NRXN1 Gene Expression an Important Marker of Treatment of Depressive Disorders? A Pilot Study
por: Skiba, Aleksandra, et al.
Publicado: (2021)

NRXN1 Deletion in Two Twins’ Genotype and Phenotype: A Clinical Case and Literature Review
por: Sciacca, Monica, et al.
Publicado: (2022)

CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing
por: Tserel, Liina, et al.
Publicado: (2014)

Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment
por: Lu, Jing, et al.
Publicado: (2020)

Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors
por: Born, Gesche, et al.
Publicado: (2015)

NRXN1 Deletion and Exposure to Methylmercury Increase Astrocyte Differentiation by Different Notch-Dependent Transcriptional Mechanisms
por: Raciti, Marilena, et al.
Publicado: (2019)

NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer
por: Yotsumoto, Takuma, et al.
Publicado: (2020)

NRXN2 Possesses a Tumor Suppressor Potential via Inhibiting the Growth of Thyroid Cancer Cells
por: Ma, Cui, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rv10sdbiudptekkr9ngsm6a125