Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging

DNA damage is presumed to be one type of stochastic macromolecular damage that contributes to aging, yet little is known about the precise mechanism by which DNA damage drives aging. Here, we attempt to address this gap in knowledge using DNA repair-deficient C. elegans and mice. ERCC1-XPF is a nucl...

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Detalles Bibliográficos
Autores principales: Gurkar, Aditi U., Robinson, Andria R., Cui, Yuxiang, Li, Xuesen, Allani, Shailaja K., Webster, Amanda, Muravia, Mariya, Fallahi, Mohammad, Weissbach, Herbert, Robbins, Paul D., Wang, Yinsheng, Kelley, Eric E., Croix, Claudette M. St., Niedernhofer, Laura J., Gill, Matthew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076207/
https://www.ncbi.nlm.nih.gov/pubmed/30031267
http://dx.doi.org/10.1016/j.redox.2018.06.005

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