Late-onset isavuconazole-induced liver injury

Antifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking. We report a case of late-onset DILI occurring after 11 months of isavuconazole therapy in a 55-year old man of Angolan desc...

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Autores principales: Bongomin, Felix, Rodriguez-Goncer, Isabel, Lorden, Carol, Otu, Akaninyene, Bazaz, Rohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076222/
https://www.ncbi.nlm.nih.gov/pubmed/30094131
http://dx.doi.org/10.1016/j.mmcr.2018.07.006
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author Bongomin, Felix
Rodriguez-Goncer, Isabel
Lorden, Carol
Otu, Akaninyene
Bazaz, Rohit
author_facet Bongomin, Felix
Rodriguez-Goncer, Isabel
Lorden, Carol
Otu, Akaninyene
Bazaz, Rohit
author_sort Bongomin, Felix
collection PubMed
description Antifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking. We report a case of late-onset DILI occurring after 11 months of isavuconazole therapy in a 55-year old man of Angolan descent on long-term antifungal therapy for the management of chronic pulmonary aspergillosis complicating previously treated pulmonary tuberculosis. The DILI could be described as idiosyncratic as it was not associated with high isavuconazole serum levels and his liver function tests returned to normal following treatment discontinuation.
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spelling pubmed-60762222018-08-09 Late-onset isavuconazole-induced liver injury Bongomin, Felix Rodriguez-Goncer, Isabel Lorden, Carol Otu, Akaninyene Bazaz, Rohit Med Mycol Case Rep Case Report Antifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking. We report a case of late-onset DILI occurring after 11 months of isavuconazole therapy in a 55-year old man of Angolan descent on long-term antifungal therapy for the management of chronic pulmonary aspergillosis complicating previously treated pulmonary tuberculosis. The DILI could be described as idiosyncratic as it was not associated with high isavuconazole serum levels and his liver function tests returned to normal following treatment discontinuation. Elsevier 2018-07-19 /pmc/articles/PMC6076222/ /pubmed/30094131 http://dx.doi.org/10.1016/j.mmcr.2018.07.006 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Bongomin, Felix
Rodriguez-Goncer, Isabel
Lorden, Carol
Otu, Akaninyene
Bazaz, Rohit
Late-onset isavuconazole-induced liver injury
title Late-onset isavuconazole-induced liver injury
title_full Late-onset isavuconazole-induced liver injury
title_fullStr Late-onset isavuconazole-induced liver injury
title_full_unstemmed Late-onset isavuconazole-induced liver injury
title_short Late-onset isavuconazole-induced liver injury
title_sort late-onset isavuconazole-induced liver injury
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076222/
https://www.ncbi.nlm.nih.gov/pubmed/30094131
http://dx.doi.org/10.1016/j.mmcr.2018.07.006
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