Clonal expansion of mtDNA deletions: different disease models assessed by digital droplet PCR in single muscle cells

Deletions in mitochondrial DNA (mtDNA) are an important cause of human disease and their accumulation has been implicated in the ageing process. As mtDNA is a high copy number genome, the coexistence of deleted and wild-type mtDNA molecules within a single cell defines heteroplasmy. When deleted mtD...

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Detalles Bibliográficos
Autores principales: Trifunov, Selena, Pyle, Angela, Valentino, Maria Lucia, Liguori, Rocco, Yu-Wai-Man, Patrick, Burté, Florence, Duff , Jennifer, Kleinle, Stephanie, Diebold, Isabel, Rugolo, Michela, Horvath, Rita, Carelli, Valerio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076247/
https://www.ncbi.nlm.nih.gov/pubmed/30076399
http://dx.doi.org/10.1038/s41598-018-30143-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076247/
https://www.ncbi.nlm.nih.gov/pubmed/30076399
http://dx.doi.org/10.1038/s41598-018-30143-z

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