A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B

The cysteine protease ATG4B is a key component of the autophagy machinery, acting to proteolytically prime and recycle its substrate MAP1LC3B. The roles of ATG4B in cancer and other diseases appear to be context dependent but are still not well understood. To help further explore ATG4B functions and...

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Detalles Bibliográficos
Autores principales: Bosc, D., Vezenkov, L., Bortnik, S., An, J., Xu, J., Choutka, C., Hannigan, A. M., Kovacic, S., Loo, S., Clark, P. G. K., Chen, G., Guay-Ross, R. N., Yang, K., Dragowska, W. H., Zhang, F., Go, N. E., Leung, A., Honson, N. S., Pfeifer, T. A., Gleave, M., Bally, M., Jones, S. J., Gorski, S. M., Young, R. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076261/
https://www.ncbi.nlm.nih.gov/pubmed/30076329
http://dx.doi.org/10.1038/s41598-018-29900-x

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