Fitting mathematical models of biochemical pathways to steady state perturbation response data without simulating perturbation experiments

Fitting Ordinary Differential Equation (ODE) models of signal transduction networks (STNs) to experimental data is a challenging problem. Computational parameter fitting algorithms simulate a model many times with different sets of parameter values until the simulated STN behaviour match closely wit...

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Detalles Bibliográficos
Autor principal: Santra, Tapesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076289/
https://www.ncbi.nlm.nih.gov/pubmed/30076370
http://dx.doi.org/10.1038/s41598-018-30118-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076289/
https://www.ncbi.nlm.nih.gov/pubmed/30076370
http://dx.doi.org/10.1038/s41598-018-30118-0

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