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An Expert Diagnostic System to Automatically Identify Asthma and Chronic Obstructive Pulmonary Disease in Clinical Settings

Respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD), are affecting a huge percentage of the world’s population with mortality rates exceeding those of lung cancer and breast cancer combined. The major challenge is the number of patients who are incorrectly diagnosed....

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Autores principales: Badnjevic, Almir, Gurbeta, Lejla, Custovic, Eddie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076307/
https://www.ncbi.nlm.nih.gov/pubmed/30076356
http://dx.doi.org/10.1038/s41598-018-30116-2
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author Badnjevic, Almir
Gurbeta, Lejla
Custovic, Eddie
author_facet Badnjevic, Almir
Gurbeta, Lejla
Custovic, Eddie
author_sort Badnjevic, Almir
collection PubMed
description Respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD), are affecting a huge percentage of the world’s population with mortality rates exceeding those of lung cancer and breast cancer combined. The major challenge is the number of patients who are incorrectly diagnosed. To address this, we developed an expert diagnostic system that can differentiate among patients with asthma, COPD or a normal lung function based on measurements of lung function and information about patient’s symptoms. To develop accurate classification algorithms, data from 3657 patients were used and then independently verified using data from 1650 patients collected over a period of two years. Our results demonstrate that the expert diagnostic system can correctly identify patients with asthma and COPD with sensitivity of 96.45% and specificity of 98.71%. Additionally, 98.71% of the patients with a normal lung function were correctly classified, which contributed to a 49.23% decrease in demand for conducting additional tests, therefore decreasing financial cost.
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spelling pubmed-60763072018-08-08 An Expert Diagnostic System to Automatically Identify Asthma and Chronic Obstructive Pulmonary Disease in Clinical Settings Badnjevic, Almir Gurbeta, Lejla Custovic, Eddie Sci Rep Article Respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD), are affecting a huge percentage of the world’s population with mortality rates exceeding those of lung cancer and breast cancer combined. The major challenge is the number of patients who are incorrectly diagnosed. To address this, we developed an expert diagnostic system that can differentiate among patients with asthma, COPD or a normal lung function based on measurements of lung function and information about patient’s symptoms. To develop accurate classification algorithms, data from 3657 patients were used and then independently verified using data from 1650 patients collected over a period of two years. Our results demonstrate that the expert diagnostic system can correctly identify patients with asthma and COPD with sensitivity of 96.45% and specificity of 98.71%. Additionally, 98.71% of the patients with a normal lung function were correctly classified, which contributed to a 49.23% decrease in demand for conducting additional tests, therefore decreasing financial cost. Nature Publishing Group UK 2018-08-03 /pmc/articles/PMC6076307/ /pubmed/30076356 http://dx.doi.org/10.1038/s41598-018-30116-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Badnjevic, Almir
Gurbeta, Lejla
Custovic, Eddie
An Expert Diagnostic System to Automatically Identify Asthma and Chronic Obstructive Pulmonary Disease in Clinical Settings
title An Expert Diagnostic System to Automatically Identify Asthma and Chronic Obstructive Pulmonary Disease in Clinical Settings
title_full An Expert Diagnostic System to Automatically Identify Asthma and Chronic Obstructive Pulmonary Disease in Clinical Settings
title_fullStr An Expert Diagnostic System to Automatically Identify Asthma and Chronic Obstructive Pulmonary Disease in Clinical Settings
title_full_unstemmed An Expert Diagnostic System to Automatically Identify Asthma and Chronic Obstructive Pulmonary Disease in Clinical Settings
title_short An Expert Diagnostic System to Automatically Identify Asthma and Chronic Obstructive Pulmonary Disease in Clinical Settings
title_sort expert diagnostic system to automatically identify asthma and chronic obstructive pulmonary disease in clinical settings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076307/
https://www.ncbi.nlm.nih.gov/pubmed/30076356
http://dx.doi.org/10.1038/s41598-018-30116-2
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