Cargando…

Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta-Analysis of Randomized Controlled Trials

INTRODUCTION: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) imposes a huge economic burden on healthcare systems worldwide. Chinese herbal injections (CHIs) are widely used to treat AECOPD. In this study, we examined the efficacy of CHIs in the treatment of AECOPD using a netw...

Descripción completa

Detalles Bibliográficos
Autores principales: Duan, Xiaojiao, Wu, Jiarui, Huang, Xingyue, Wang, Kaihuan, Zhao, Yi, Zhang, Dan, Liu, Xinkui, Zhang, Xiaomeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076913/
https://www.ncbi.nlm.nih.gov/pubmed/30105066
http://dx.doi.org/10.1155/2018/7942936
_version_ 1783344804670734336
author Duan, Xiaojiao
Wu, Jiarui
Huang, Xingyue
Wang, Kaihuan
Zhao, Yi
Zhang, Dan
Liu, Xinkui
Zhang, Xiaomeng
author_facet Duan, Xiaojiao
Wu, Jiarui
Huang, Xingyue
Wang, Kaihuan
Zhao, Yi
Zhang, Dan
Liu, Xinkui
Zhang, Xiaomeng
author_sort Duan, Xiaojiao
collection PubMed
description INTRODUCTION: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) imposes a huge economic burden on healthcare systems worldwide. Chinese herbal injections (CHIs) are widely used to treat AECOPD. In this study, we examined the efficacy of CHIs in the treatment of AECOPD using a network meta-analysis (NMA). METHODS: Literature search was conducted from electronic databases of randomized controlled trials (RCTs) on CHIs plus Western medicine (WM) versus WM. WinBUGS 1.4.3 and STATA 12.0 were adopted to compute calculations and prepare graphs, respectively. RESULTS: We included 155 RCTs with 13,218 patients. The results revealed that Danhong injection (DH) + WM had the greatest therapeutic potential in terms of rate of clinical efficacy (RCE). In addition, in comprehensively improving RCE and FEV(1)%, and RCE and C-reactive protein, Huangqi injection (HQ) +WM was associated with preferable effects. Similarly, Xixinnao injection + WM, Reduning injection (RDN) +WM, and HQ+WM had a favorable effect on RCE and PaO(2). The effect of RDN+WM was favorable in all outcomes except RCE. The safety of CHIs needs to be further assessed. CONCLUSIONS: Based on this NMA, DH+WM, HQ+WM, and RDN+WM were potential optimal therapies in AECOPD and their safety should be strictly monitored.
format Online
Article
Text
id pubmed-6076913
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-60769132018-08-13 Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta-Analysis of Randomized Controlled Trials Duan, Xiaojiao Wu, Jiarui Huang, Xingyue Wang, Kaihuan Zhao, Yi Zhang, Dan Liu, Xinkui Zhang, Xiaomeng Evid Based Complement Alternat Med Review Article INTRODUCTION: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) imposes a huge economic burden on healthcare systems worldwide. Chinese herbal injections (CHIs) are widely used to treat AECOPD. In this study, we examined the efficacy of CHIs in the treatment of AECOPD using a network meta-analysis (NMA). METHODS: Literature search was conducted from electronic databases of randomized controlled trials (RCTs) on CHIs plus Western medicine (WM) versus WM. WinBUGS 1.4.3 and STATA 12.0 were adopted to compute calculations and prepare graphs, respectively. RESULTS: We included 155 RCTs with 13,218 patients. The results revealed that Danhong injection (DH) + WM had the greatest therapeutic potential in terms of rate of clinical efficacy (RCE). In addition, in comprehensively improving RCE and FEV(1)%, and RCE and C-reactive protein, Huangqi injection (HQ) +WM was associated with preferable effects. Similarly, Xixinnao injection + WM, Reduning injection (RDN) +WM, and HQ+WM had a favorable effect on RCE and PaO(2). The effect of RDN+WM was favorable in all outcomes except RCE. The safety of CHIs needs to be further assessed. CONCLUSIONS: Based on this NMA, DH+WM, HQ+WM, and RDN+WM were potential optimal therapies in AECOPD and their safety should be strictly monitored. Hindawi 2018-07-17 /pmc/articles/PMC6076913/ /pubmed/30105066 http://dx.doi.org/10.1155/2018/7942936 Text en Copyright © 2018 Xiaojiao Duan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Duan, Xiaojiao
Wu, Jiarui
Huang, Xingyue
Wang, Kaihuan
Zhao, Yi
Zhang, Dan
Liu, Xinkui
Zhang, Xiaomeng
Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
title Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
title_full Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
title_fullStr Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
title_short Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
title_sort comparative efficacy of chinese herbal injections for treating acute exacerbation of chronic obstructive pulmonary disease: a bayesian network meta-analysis of randomized controlled trials
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076913/
https://www.ncbi.nlm.nih.gov/pubmed/30105066
http://dx.doi.org/10.1155/2018/7942936
work_keys_str_mv AT duanxiaojiao comparativeefficacyofchineseherbalinjectionsfortreatingacuteexacerbationofchronicobstructivepulmonarydiseaseabayesiannetworkmetaanalysisofrandomizedcontrolledtrials
AT wujiarui comparativeefficacyofchineseherbalinjectionsfortreatingacuteexacerbationofchronicobstructivepulmonarydiseaseabayesiannetworkmetaanalysisofrandomizedcontrolledtrials
AT huangxingyue comparativeefficacyofchineseherbalinjectionsfortreatingacuteexacerbationofchronicobstructivepulmonarydiseaseabayesiannetworkmetaanalysisofrandomizedcontrolledtrials
AT wangkaihuan comparativeefficacyofchineseherbalinjectionsfortreatingacuteexacerbationofchronicobstructivepulmonarydiseaseabayesiannetworkmetaanalysisofrandomizedcontrolledtrials
AT zhaoyi comparativeefficacyofchineseherbalinjectionsfortreatingacuteexacerbationofchronicobstructivepulmonarydiseaseabayesiannetworkmetaanalysisofrandomizedcontrolledtrials
AT zhangdan comparativeefficacyofchineseherbalinjectionsfortreatingacuteexacerbationofchronicobstructivepulmonarydiseaseabayesiannetworkmetaanalysisofrandomizedcontrolledtrials
AT liuxinkui comparativeefficacyofchineseherbalinjectionsfortreatingacuteexacerbationofchronicobstructivepulmonarydiseaseabayesiannetworkmetaanalysisofrandomizedcontrolledtrials
AT zhangxiaomeng comparativeefficacyofchineseherbalinjectionsfortreatingacuteexacerbationofchronicobstructivepulmonarydiseaseabayesiannetworkmetaanalysisofrandomizedcontrolledtrials