A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications

Hepatocellular carcinoma (HCC) has the second highest mortality rate worldwide among all cancers. Previous studies have revealed the significant involvement of long noncoding RNAs (lncRNAs) in numerous human cancers including HCC. Both oncogenic and tumor repressive lncRNAs have been identified and...

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Detalles Bibliográficos
Autores principales: Hu, Xiaoge, Jiang, Jiahong, Xu, Qiuran, Ni, Chao, Yang, Liu, Huang, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076971/
https://www.ncbi.nlm.nih.gov/pubmed/30105249
http://dx.doi.org/10.1155/2018/8126208
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author Hu, Xiaoge
Jiang, Jiahong
Xu, Qiuran
Ni, Chao
Yang, Liu
Huang, Dongsheng
author_facet Hu, Xiaoge
Jiang, Jiahong
Xu, Qiuran
Ni, Chao
Yang, Liu
Huang, Dongsheng
author_sort Hu, Xiaoge
collection PubMed
description Hepatocellular carcinoma (HCC) has the second highest mortality rate worldwide among all cancers. Previous studies have revealed the significant involvement of long noncoding RNAs (lncRNAs) in numerous human cancers including HCC. Both oncogenic and tumor repressive lncRNAs have been identified and implicated in the complex process of hepatocarcinogenesis. They can be further explored as prospective diagnostic, prognostic, and therapeutic markers for HCC. An in-depth understanding of lncRNAs' mechanism in HCC is therefore required to fully explore their potential role. In the current review, we will concentrate on the underlying function, molecular mechanisms, and potential clinical implications of lncRNA in HCC.
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spelling pubmed-60769712018-08-13 A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications Hu, Xiaoge Jiang, Jiahong Xu, Qiuran Ni, Chao Yang, Liu Huang, Dongsheng Biomed Res Int Review Article Hepatocellular carcinoma (HCC) has the second highest mortality rate worldwide among all cancers. Previous studies have revealed the significant involvement of long noncoding RNAs (lncRNAs) in numerous human cancers including HCC. Both oncogenic and tumor repressive lncRNAs have been identified and implicated in the complex process of hepatocarcinogenesis. They can be further explored as prospective diagnostic, prognostic, and therapeutic markers for HCC. An in-depth understanding of lncRNAs' mechanism in HCC is therefore required to fully explore their potential role. In the current review, we will concentrate on the underlying function, molecular mechanisms, and potential clinical implications of lncRNA in HCC. Hindawi 2018-07-09 /pmc/articles/PMC6076971/ /pubmed/30105249 http://dx.doi.org/10.1155/2018/8126208 Text en Copyright © 2018 Xiaoge Hu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hu, Xiaoge
Jiang, Jiahong
Xu, Qiuran
Ni, Chao
Yang, Liu
Huang, Dongsheng
A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications
title A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications
title_full A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications
title_fullStr A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications
title_full_unstemmed A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications
title_short A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications
title_sort systematic review of long noncoding rnas in hepatocellular carcinoma: molecular mechanism and clinical implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076971/
https://www.ncbi.nlm.nih.gov/pubmed/30105249
http://dx.doi.org/10.1155/2018/8126208
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