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Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh

BACKGROUND: Because reports of bronchiolitis obliterans organizing pneumonia (BOOP) are lacking from the Middle East, we conducted a retrospective review of of all histopathologically proven cases of BOOP over a 10-year period at three tertiary care hospitals in Riyadh and describe the clinical feat...

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Autores principales: Alsaghir, Abdullah H., Al-Mobeireek, Abdullah F., Al-Jahdali, Hamdan, Al-Eithan, Abdulsalam, Al-Otair, Hadil, Al-Dayel, Fouad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077020/
https://www.ncbi.nlm.nih.gov/pubmed/17277498
http://dx.doi.org/10.5144/0256-4947.2007.32
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author Alsaghir, Abdullah H.
Al-Mobeireek, Abdullah F.
Al-Jahdali, Hamdan
Al-Eithan, Abdulsalam
Al-Otair, Hadil
Al-Dayel, Fouad
author_facet Alsaghir, Abdullah H.
Al-Mobeireek, Abdullah F.
Al-Jahdali, Hamdan
Al-Eithan, Abdulsalam
Al-Otair, Hadil
Al-Dayel, Fouad
author_sort Alsaghir, Abdullah H.
collection PubMed
description BACKGROUND: Because reports of bronchiolitis obliterans organizing pneumonia (BOOP) are lacking from the Middle East, we conducted a retrospective review of of all histopathologically proven cases of BOOP over a 10-year period at three tertiary care hospitals in Riyadh and describe the clinical features and outcome. METHODS: Charts at the three hospitals were searched using a specific code for BOOP or cryptogenic organizing pneumonia (COP). Lung specimens had to show histological proof of BOOP with a compatible clinical picture. Chest radiographs and high-resolution CT scans were reviewed. RESULTS: Twenty cases of biopsy-proven BOOP had well-documented clinical and radiographic data. There were 11 males and 9 females (mean age, 58 years; range, 42–78). The clinical presentation of BOOP was acute or subacute pneumonia-like illness with cough (85%), fever (70%) dyspnea, (85%) and crackles (80%). The most frequent radiological pattern was a bilateral alveolar infiltrate. The most common abnormality on pulmonary function testing (n=14) was a restrictive pattern (11 patients). Most patients (70%) had no underlying cause (idiopathic BOOP). Other associations included thyroid cancer, rheumatoid arthritis, syphilis and Wegner's granulomatosis. Ten patients (50%) had a complete response to steroids, 6 (30%) had a partial response and 3 (15.8%) with secondary BOOP had rapid progressive respiratory failure and died. CONCLUSION: The clinical presentation of BOOP in our patients is similar to other reported series. A favorable outcome occurs in the majority of cases. However, BOOP may occasionally be associated with a poor prognosis, particularly when associated with an underlying disease.
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spelling pubmed-60770202018-09-21 Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh Alsaghir, Abdullah H. Al-Mobeireek, Abdullah F. Al-Jahdali, Hamdan Al-Eithan, Abdulsalam Al-Otair, Hadil Al-Dayel, Fouad Ann Saudi Med Original Article BACKGROUND: Because reports of bronchiolitis obliterans organizing pneumonia (BOOP) are lacking from the Middle East, we conducted a retrospective review of of all histopathologically proven cases of BOOP over a 10-year period at three tertiary care hospitals in Riyadh and describe the clinical features and outcome. METHODS: Charts at the three hospitals were searched using a specific code for BOOP or cryptogenic organizing pneumonia (COP). Lung specimens had to show histological proof of BOOP with a compatible clinical picture. Chest radiographs and high-resolution CT scans were reviewed. RESULTS: Twenty cases of biopsy-proven BOOP had well-documented clinical and radiographic data. There were 11 males and 9 females (mean age, 58 years; range, 42–78). The clinical presentation of BOOP was acute or subacute pneumonia-like illness with cough (85%), fever (70%) dyspnea, (85%) and crackles (80%). The most frequent radiological pattern was a bilateral alveolar infiltrate. The most common abnormality on pulmonary function testing (n=14) was a restrictive pattern (11 patients). Most patients (70%) had no underlying cause (idiopathic BOOP). Other associations included thyroid cancer, rheumatoid arthritis, syphilis and Wegner's granulomatosis. Ten patients (50%) had a complete response to steroids, 6 (30%) had a partial response and 3 (15.8%) with secondary BOOP had rapid progressive respiratory failure and died. CONCLUSION: The clinical presentation of BOOP in our patients is similar to other reported series. A favorable outcome occurs in the majority of cases. However, BOOP may occasionally be associated with a poor prognosis, particularly when associated with an underlying disease. King Faisal Specialist Hospital and Research Centre 2007 /pmc/articles/PMC6077020/ /pubmed/17277498 http://dx.doi.org/10.5144/0256-4947.2007.32 Text en Copyright © 2007, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Alsaghir, Abdullah H.
Al-Mobeireek, Abdullah F.
Al-Jahdali, Hamdan
Al-Eithan, Abdulsalam
Al-Otair, Hadil
Al-Dayel, Fouad
Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh
title Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh
title_full Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh
title_fullStr Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh
title_full_unstemmed Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh
title_short Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh
title_sort bronchiolitis obliterans organizing pneumonia: experience at three hospitals in riyadh
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077020/
https://www.ncbi.nlm.nih.gov/pubmed/17277498
http://dx.doi.org/10.5144/0256-4947.2007.32
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