Recent advances in design of new urease inhibitors: A review

Urease is a nickel-dependent metalloenzyme found in plants, some bacteria, and fungi. Bacterial enzyme is of special importance since it has been demonstrated as a potent virulence factor for some species. Especially it is central to Helicobacter pylori metabolism and virulence being necessary for i...

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Detalles Bibliográficos
Autores principales: Kafarski, Paweł, Talma, Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077125/
https://www.ncbi.nlm.nih.gov/pubmed/30094085
http://dx.doi.org/10.1016/j.jare.2018.01.007
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author Kafarski, Paweł
Talma, Michał
author_facet Kafarski, Paweł
Talma, Michał
author_sort Kafarski, Paweł
collection PubMed
description Urease is a nickel-dependent metalloenzyme found in plants, some bacteria, and fungi. Bacterial enzyme is of special importance since it has been demonstrated as a potent virulence factor for some species. Especially it is central to Helicobacter pylori metabolism and virulence being necessary for its colonization of the gastric mucosa, and is a potent immunogen that elicits a vigorous immune response. Therefore, it is not surprising that efforts to design, synthesize and evaluate of new inhibitors of urease are and active field of medicinal chemistry. In this paper recent advances on this field are reviewed.
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spelling pubmed-60771252018-08-09 Recent advances in design of new urease inhibitors: A review Kafarski, Paweł Talma, Michał J Adv Res Article Urease is a nickel-dependent metalloenzyme found in plants, some bacteria, and fungi. Bacterial enzyme is of special importance since it has been demonstrated as a potent virulence factor for some species. Especially it is central to Helicobacter pylori metabolism and virulence being necessary for its colonization of the gastric mucosa, and is a potent immunogen that elicits a vigorous immune response. Therefore, it is not surprising that efforts to design, synthesize and evaluate of new inhibitors of urease are and active field of medicinal chemistry. In this paper recent advances on this field are reviewed. Elsevier 2018-01-31 /pmc/articles/PMC6077125/ /pubmed/30094085 http://dx.doi.org/10.1016/j.jare.2018.01.007 Text en © 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kafarski, Paweł
Talma, Michał
Recent advances in design of new urease inhibitors: A review
title Recent advances in design of new urease inhibitors: A review
title_full Recent advances in design of new urease inhibitors: A review
title_fullStr Recent advances in design of new urease inhibitors: A review
title_full_unstemmed Recent advances in design of new urease inhibitors: A review
title_short Recent advances in design of new urease inhibitors: A review
title_sort recent advances in design of new urease inhibitors: a review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077125/
https://www.ncbi.nlm.nih.gov/pubmed/30094085
http://dx.doi.org/10.1016/j.jare.2018.01.007
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