A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors

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Delivering genes selectively to the therapeutically relevant cell type is among the prime goals of vector development. Here, we present a high-throughput selection and screening process that identifies designed ankyrin repeat proteins (DARPins) optimally suited for receptor-targeted gene delivery us...

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Detalles Bibliográficos
Autores principales: Hartmann, Jessica, Münch, Robert C., Freiling, Ruth-Therese, Schneider, Irene C., Dreier, Birgit, Samukange, Washington, Koch, Joachim, Seeger, Markus A., Plückthun, Andreas, Buchholz, Christian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077149/
https://www.ncbi.nlm.nih.gov/pubmed/30101151
http://dx.doi.org/10.1016/j.omtm.2018.07.001

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