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Dietary Copper Intake and Its Association With Telomere Length: A Population Based Study

Background: Telomere is regarded as the fundamental aspect of cellular aging and copper is recognized as one of the most essential trace elements. The role of dietary copper intake in telomere length maintenance is seldom examined. This study aims to investigate if telomere length is to be associate...

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Autores principales: Lin, Zhu, Gao, Hongmei, Wang, Bing, Wang, Yongqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077216/
https://www.ncbi.nlm.nih.gov/pubmed/30105003
http://dx.doi.org/10.3389/fendo.2018.00404
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author Lin, Zhu
Gao, Hongmei
Wang, Bing
Wang, Yongqiang
author_facet Lin, Zhu
Gao, Hongmei
Wang, Bing
Wang, Yongqiang
author_sort Lin, Zhu
collection PubMed
description Background: Telomere is regarded as the fundamental aspect of cellular aging and copper is recognized as one of the most essential trace elements. The role of dietary copper intake in telomere length maintenance is seldom examined. This study aims to investigate if telomere length is to be associated with daily dietary copper intake. Methods: We used epidemiological data from a large national population-based health and nutrition survey. Dietary intake was assessed during the 24–h period before the interview date when blood sample was collected. Telomere length was measured from blood leukocyte using PCR method. The relationship between telomere length and dietary copper intake was assessed using multivariable linear regression models. We also examined if obesity, measured by body mass index, could modify the observed association. Results: There are 7,324 participants had both leukocyte telomere length measured and dietary copper intake assessed, around 48.0% of them were men. Telomere length was longer in women than that in men (1.05 ± 0.26 vs. 1.00 ± 0.26 T/S ratio), while dietary copper intake was less in women than that in men (1.12 ± 0.80 vs. 1.51 ± 1.61 mg). After controlling for age, sex, ethnicity, physical activity, current smoking status, hypertension, cardiovascular diseases, and body mass index in the multivariable linear regression models, one unit increase of log-transformed dietary copper intake was significantly associated with longer telomere length (β = 0.02, 95% confidence interval: 0.01, 0.04). We did not find a significant sex difference for this association. Conclusions: Dietary copper intake was significantly associated telomere length.The role of copper in human health might be involved in biological aging process.
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spelling pubmed-60772162018-08-13 Dietary Copper Intake and Its Association With Telomere Length: A Population Based Study Lin, Zhu Gao, Hongmei Wang, Bing Wang, Yongqiang Front Endocrinol (Lausanne) Endocrinology Background: Telomere is regarded as the fundamental aspect of cellular aging and copper is recognized as one of the most essential trace elements. The role of dietary copper intake in telomere length maintenance is seldom examined. This study aims to investigate if telomere length is to be associated with daily dietary copper intake. Methods: We used epidemiological data from a large national population-based health and nutrition survey. Dietary intake was assessed during the 24–h period before the interview date when blood sample was collected. Telomere length was measured from blood leukocyte using PCR method. The relationship between telomere length and dietary copper intake was assessed using multivariable linear regression models. We also examined if obesity, measured by body mass index, could modify the observed association. Results: There are 7,324 participants had both leukocyte telomere length measured and dietary copper intake assessed, around 48.0% of them were men. Telomere length was longer in women than that in men (1.05 ± 0.26 vs. 1.00 ± 0.26 T/S ratio), while dietary copper intake was less in women than that in men (1.12 ± 0.80 vs. 1.51 ± 1.61 mg). After controlling for age, sex, ethnicity, physical activity, current smoking status, hypertension, cardiovascular diseases, and body mass index in the multivariable linear regression models, one unit increase of log-transformed dietary copper intake was significantly associated with longer telomere length (β = 0.02, 95% confidence interval: 0.01, 0.04). We did not find a significant sex difference for this association. Conclusions: Dietary copper intake was significantly associated telomere length.The role of copper in human health might be involved in biological aging process. Frontiers Media S.A. 2018-07-30 /pmc/articles/PMC6077216/ /pubmed/30105003 http://dx.doi.org/10.3389/fendo.2018.00404 Text en Copyright © 2018 Lin, Gao, Wang and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Lin, Zhu
Gao, Hongmei
Wang, Bing
Wang, Yongqiang
Dietary Copper Intake and Its Association With Telomere Length: A Population Based Study
title Dietary Copper Intake and Its Association With Telomere Length: A Population Based Study
title_full Dietary Copper Intake and Its Association With Telomere Length: A Population Based Study
title_fullStr Dietary Copper Intake and Its Association With Telomere Length: A Population Based Study
title_full_unstemmed Dietary Copper Intake and Its Association With Telomere Length: A Population Based Study
title_short Dietary Copper Intake and Its Association With Telomere Length: A Population Based Study
title_sort dietary copper intake and its association with telomere length: a population based study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077216/
https://www.ncbi.nlm.nih.gov/pubmed/30105003
http://dx.doi.org/10.3389/fendo.2018.00404
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