Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity

RNA-binding protein aggregation is a pathological hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). To gain better insight into the molecular interactions underlying this process, we investigated FUS, which is...

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Detalles Bibliográficos
Autores principales: Bogaert, Elke, Boeynaems, Steven, Kato, Masato, Guo, Lin, Caulfield, Thomas R., Steyaert, Jolien, Scheveneels, Wendy, Wilmans, Nathalie, Haeck, Wanda, Hersmus, Nicole, Schymkowitz, Joost, Rousseau, Frederic, Shorter, James, Callaerts, Patrick, Robberecht, Wim, Van Damme, Philip, Van Den Bosch, Ludo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077250/
https://www.ncbi.nlm.nih.gov/pubmed/30021151
http://dx.doi.org/10.1016/j.celrep.2018.06.070

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