Cargando…
Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
BACKGROUND/AIMS: This study aimed to elucidate the prevalence of hepatitis B virus (HBV) serologic markers in Korean patients newly diagnosed with, but not yet treated for inflammatory bowel disease (IBD). METHODS: We prospectively enrolled 210 patients newly diagnosed with IBD (109 with ulcerative...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association for the Study of Intestinal Diseases
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077318/ https://www.ncbi.nlm.nih.gov/pubmed/30090039 http://dx.doi.org/10.5217/ir.2018.16.3.400 |
_version_ | 1783344887076225024 |
---|---|
author | Yeo, Seong Jae Lee, Hyun Seok Jang, Byung Ik Kim, Eun Soo Jeon, Seong Woo Kim, Sung Kook Kim, Kyeong Ok Lee, Yoo Jin Lee, Hyun Jik Park, Kyung Sik Jung, Yun Jin Kim, Eun Young Yang, Chang Heon |
author_facet | Yeo, Seong Jae Lee, Hyun Seok Jang, Byung Ik Kim, Eun Soo Jeon, Seong Woo Kim, Sung Kook Kim, Kyeong Ok Lee, Yoo Jin Lee, Hyun Jik Park, Kyung Sik Jung, Yun Jin Kim, Eun Young Yang, Chang Heon |
author_sort | Yeo, Seong Jae |
collection | PubMed |
description | BACKGROUND/AIMS: This study aimed to elucidate the prevalence of hepatitis B virus (HBV) serologic markers in Korean patients newly diagnosed with, but not yet treated for inflammatory bowel disease (IBD). METHODS: We prospectively enrolled 210 patients newly diagnosed with IBD (109 with ulcerative colitis and 101 with Crohn's disease). Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels were measured and compared with those of 1,100 sex- and age-matched controls. RESULTS: The prevalence of chronic HBV infection (positive HBsAg, positive anti-HBc, and negative anti-HBs results) and past infection (negative HBsAg, positive anti-HBc, and positive or negative anti-HBs results) were not significantly different between the patients and controls (chronic HBV infection: IBD, 3.8% vs. control, 4.9%, P=0.596; past infection: IBD, 26.2% vs. control, 28.8%, P=0.625). The patients with IBD aged <20 years were at a higher susceptibility risk (nonimmune) for HBV infection than the controls (IBD, 41.5% vs. control, 22.4%; P=0.018). In the multivariate analysis, an age of <20 years (P=0.024) and symptom duration of ≥12 months before diagnosis (P=0.027) were identified as independent risk factors for nonimmunity against HBV infection. CONCLUSIONS: The patients newly diagnosed with IBD were susceptible to HBV infection. The frequency of nonimmunity was high, especially in the patients aged <20 years and those with a longer duration of symptoms before diagnosis. Therefore, it is necessary to screen for HBV serologic markers and generate a detailed vaccination plan for patients newly diagnosed with IBD. |
format | Online Article Text |
id | pubmed-6077318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Association for the Study of Intestinal Diseases |
record_format | MEDLINE/PubMed |
spelling | pubmed-60773182018-08-08 Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease Yeo, Seong Jae Lee, Hyun Seok Jang, Byung Ik Kim, Eun Soo Jeon, Seong Woo Kim, Sung Kook Kim, Kyeong Ok Lee, Yoo Jin Lee, Hyun Jik Park, Kyung Sik Jung, Yun Jin Kim, Eun Young Yang, Chang Heon Intest Res Original Article BACKGROUND/AIMS: This study aimed to elucidate the prevalence of hepatitis B virus (HBV) serologic markers in Korean patients newly diagnosed with, but not yet treated for inflammatory bowel disease (IBD). METHODS: We prospectively enrolled 210 patients newly diagnosed with IBD (109 with ulcerative colitis and 101 with Crohn's disease). Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels were measured and compared with those of 1,100 sex- and age-matched controls. RESULTS: The prevalence of chronic HBV infection (positive HBsAg, positive anti-HBc, and negative anti-HBs results) and past infection (negative HBsAg, positive anti-HBc, and positive or negative anti-HBs results) were not significantly different between the patients and controls (chronic HBV infection: IBD, 3.8% vs. control, 4.9%, P=0.596; past infection: IBD, 26.2% vs. control, 28.8%, P=0.625). The patients with IBD aged <20 years were at a higher susceptibility risk (nonimmune) for HBV infection than the controls (IBD, 41.5% vs. control, 22.4%; P=0.018). In the multivariate analysis, an age of <20 years (P=0.024) and symptom duration of ≥12 months before diagnosis (P=0.027) were identified as independent risk factors for nonimmunity against HBV infection. CONCLUSIONS: The patients newly diagnosed with IBD were susceptible to HBV infection. The frequency of nonimmunity was high, especially in the patients aged <20 years and those with a longer duration of symptoms before diagnosis. Therefore, it is necessary to screen for HBV serologic markers and generate a detailed vaccination plan for patients newly diagnosed with IBD. Korean Association for the Study of Intestinal Diseases 2018-07 2018-07-27 /pmc/articles/PMC6077318/ /pubmed/30090039 http://dx.doi.org/10.5217/ir.2018.16.3.400 Text en © Copyright 2018. Korean Association for the Study of Intestinal Diseases. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yeo, Seong Jae Lee, Hyun Seok Jang, Byung Ik Kim, Eun Soo Jeon, Seong Woo Kim, Sung Kook Kim, Kyeong Ok Lee, Yoo Jin Lee, Hyun Jik Park, Kyung Sik Jung, Yun Jin Kim, Eun Young Yang, Chang Heon Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease |
title | Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease |
title_full | Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease |
title_fullStr | Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease |
title_full_unstemmed | Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease |
title_short | Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease |
title_sort | nonimmunity against hepatitis b virus infection in patients newly diagnosed with inflammatory bowel disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077318/ https://www.ncbi.nlm.nih.gov/pubmed/30090039 http://dx.doi.org/10.5217/ir.2018.16.3.400 |
work_keys_str_mv | AT yeoseongjae nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT leehyunseok nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT jangbyungik nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT kimeunsoo nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT jeonseongwoo nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT kimsungkook nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT kimkyeongok nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT leeyoojin nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT leehyunjik nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT parkkyungsik nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT jungyunjin nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT kimeunyoung nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT yangchangheon nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease AT nonimmunityagainsthepatitisbvirusinfectioninpatientsnewlydiagnosedwithinflammatoryboweldisease |