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Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease

BACKGROUND/AIMS: This study aimed to elucidate the prevalence of hepatitis B virus (HBV) serologic markers in Korean patients newly diagnosed with, but not yet treated for inflammatory bowel disease (IBD). METHODS: We prospectively enrolled 210 patients newly diagnosed with IBD (109 with ulcerative...

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Autores principales: Yeo, Seong Jae, Lee, Hyun Seok, Jang, Byung Ik, Kim, Eun Soo, Jeon, Seong Woo, Kim, Sung Kook, Kim, Kyeong Ok, Lee, Yoo Jin, Lee, Hyun Jik, Park, Kyung Sik, Jung, Yun Jin, Kim, Eun Young, Yang, Chang Heon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for the Study of Intestinal Diseases 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077318/
https://www.ncbi.nlm.nih.gov/pubmed/30090039
http://dx.doi.org/10.5217/ir.2018.16.3.400
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author Yeo, Seong Jae
Lee, Hyun Seok
Jang, Byung Ik
Kim, Eun Soo
Jeon, Seong Woo
Kim, Sung Kook
Kim, Kyeong Ok
Lee, Yoo Jin
Lee, Hyun Jik
Park, Kyung Sik
Jung, Yun Jin
Kim, Eun Young
Yang, Chang Heon
author_facet Yeo, Seong Jae
Lee, Hyun Seok
Jang, Byung Ik
Kim, Eun Soo
Jeon, Seong Woo
Kim, Sung Kook
Kim, Kyeong Ok
Lee, Yoo Jin
Lee, Hyun Jik
Park, Kyung Sik
Jung, Yun Jin
Kim, Eun Young
Yang, Chang Heon
author_sort Yeo, Seong Jae
collection PubMed
description BACKGROUND/AIMS: This study aimed to elucidate the prevalence of hepatitis B virus (HBV) serologic markers in Korean patients newly diagnosed with, but not yet treated for inflammatory bowel disease (IBD). METHODS: We prospectively enrolled 210 patients newly diagnosed with IBD (109 with ulcerative colitis and 101 with Crohn's disease). Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels were measured and compared with those of 1,100 sex- and age-matched controls. RESULTS: The prevalence of chronic HBV infection (positive HBsAg, positive anti-HBc, and negative anti-HBs results) and past infection (negative HBsAg, positive anti-HBc, and positive or negative anti-HBs results) were not significantly different between the patients and controls (chronic HBV infection: IBD, 3.8% vs. control, 4.9%, P=0.596; past infection: IBD, 26.2% vs. control, 28.8%, P=0.625). The patients with IBD aged <20 years were at a higher susceptibility risk (nonimmune) for HBV infection than the controls (IBD, 41.5% vs. control, 22.4%; P=0.018). In the multivariate analysis, an age of <20 years (P=0.024) and symptom duration of ≥12 months before diagnosis (P=0.027) were identified as independent risk factors for nonimmunity against HBV infection. CONCLUSIONS: The patients newly diagnosed with IBD were susceptible to HBV infection. The frequency of nonimmunity was high, especially in the patients aged <20 years and those with a longer duration of symptoms before diagnosis. Therefore, it is necessary to screen for HBV serologic markers and generate a detailed vaccination plan for patients newly diagnosed with IBD.
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spelling pubmed-60773182018-08-08 Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease Yeo, Seong Jae Lee, Hyun Seok Jang, Byung Ik Kim, Eun Soo Jeon, Seong Woo Kim, Sung Kook Kim, Kyeong Ok Lee, Yoo Jin Lee, Hyun Jik Park, Kyung Sik Jung, Yun Jin Kim, Eun Young Yang, Chang Heon Intest Res Original Article BACKGROUND/AIMS: This study aimed to elucidate the prevalence of hepatitis B virus (HBV) serologic markers in Korean patients newly diagnosed with, but not yet treated for inflammatory bowel disease (IBD). METHODS: We prospectively enrolled 210 patients newly diagnosed with IBD (109 with ulcerative colitis and 101 with Crohn's disease). Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels were measured and compared with those of 1,100 sex- and age-matched controls. RESULTS: The prevalence of chronic HBV infection (positive HBsAg, positive anti-HBc, and negative anti-HBs results) and past infection (negative HBsAg, positive anti-HBc, and positive or negative anti-HBs results) were not significantly different between the patients and controls (chronic HBV infection: IBD, 3.8% vs. control, 4.9%, P=0.596; past infection: IBD, 26.2% vs. control, 28.8%, P=0.625). The patients with IBD aged <20 years were at a higher susceptibility risk (nonimmune) for HBV infection than the controls (IBD, 41.5% vs. control, 22.4%; P=0.018). In the multivariate analysis, an age of <20 years (P=0.024) and symptom duration of ≥12 months before diagnosis (P=0.027) were identified as independent risk factors for nonimmunity against HBV infection. CONCLUSIONS: The patients newly diagnosed with IBD were susceptible to HBV infection. The frequency of nonimmunity was high, especially in the patients aged <20 years and those with a longer duration of symptoms before diagnosis. Therefore, it is necessary to screen for HBV serologic markers and generate a detailed vaccination plan for patients newly diagnosed with IBD. Korean Association for the Study of Intestinal Diseases 2018-07 2018-07-27 /pmc/articles/PMC6077318/ /pubmed/30090039 http://dx.doi.org/10.5217/ir.2018.16.3.400 Text en © Copyright 2018. Korean Association for the Study of Intestinal Diseases. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yeo, Seong Jae
Lee, Hyun Seok
Jang, Byung Ik
Kim, Eun Soo
Jeon, Seong Woo
Kim, Sung Kook
Kim, Kyeong Ok
Lee, Yoo Jin
Lee, Hyun Jik
Park, Kyung Sik
Jung, Yun Jin
Kim, Eun Young
Yang, Chang Heon
Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
title Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
title_full Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
title_fullStr Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
title_full_unstemmed Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
title_short Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease
title_sort nonimmunity against hepatitis b virus infection in patients newly diagnosed with inflammatory bowel disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077318/
https://www.ncbi.nlm.nih.gov/pubmed/30090039
http://dx.doi.org/10.5217/ir.2018.16.3.400
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