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An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin

A battery of toxicological studies was conducted in accordance with international guidelines to investigate the genotoxicity and repeated-dose oral toxicity in rats of synthetic curcumin (VEAMIN 99, >99% purity). There was no evidence of mutagenicity in a bacterial reverse mutation test, whereas...

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Autores principales: Damarla, Sreenivasa Rao, Komma, Rajesh, Bhatnagar, Upendra, Rajesh, Navin, Mulla, Sadik Mohmad Abdulhamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077508/
https://www.ncbi.nlm.nih.gov/pubmed/30111997
http://dx.doi.org/10.1155/2018/6872753
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author Damarla, Sreenivasa Rao
Komma, Rajesh
Bhatnagar, Upendra
Rajesh, Navin
Mulla, Sadik Mohmad Abdulhamid
author_facet Damarla, Sreenivasa Rao
Komma, Rajesh
Bhatnagar, Upendra
Rajesh, Navin
Mulla, Sadik Mohmad Abdulhamid
author_sort Damarla, Sreenivasa Rao
collection PubMed
description A battery of toxicological studies was conducted in accordance with international guidelines to investigate the genotoxicity and repeated-dose oral toxicity in rats of synthetic curcumin (VEAMIN 99, >99% purity). There was no evidence of mutagenicity in a bacterial reverse mutation test, whereas an in vitro mammalian chromosomal aberration test was positive for induction of chromosomal aberrations which is in line with results reported for natural curcumin. There was no evidence of genotoxicity in an in vivo mammalian micronucleus test. Synthetic curcumin did not cause mortality or toxic effects in a 90-day repeated-dose oral toxicity study at daily doses of 250, 500, or 1000 mg/kg body weight (bw)/day (administered by gavage in a split dose). The no observed adverse effect level (NOAEL) determined from the 90-day study was 1000 mg/kg bw/day for both male and female Wistar rats.
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spelling pubmed-60775082018-08-15 An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin Damarla, Sreenivasa Rao Komma, Rajesh Bhatnagar, Upendra Rajesh, Navin Mulla, Sadik Mohmad Abdulhamid J Toxicol Research Article A battery of toxicological studies was conducted in accordance with international guidelines to investigate the genotoxicity and repeated-dose oral toxicity in rats of synthetic curcumin (VEAMIN 99, >99% purity). There was no evidence of mutagenicity in a bacterial reverse mutation test, whereas an in vitro mammalian chromosomal aberration test was positive for induction of chromosomal aberrations which is in line with results reported for natural curcumin. There was no evidence of genotoxicity in an in vivo mammalian micronucleus test. Synthetic curcumin did not cause mortality or toxic effects in a 90-day repeated-dose oral toxicity study at daily doses of 250, 500, or 1000 mg/kg body weight (bw)/day (administered by gavage in a split dose). The no observed adverse effect level (NOAEL) determined from the 90-day study was 1000 mg/kg bw/day for both male and female Wistar rats. Hindawi 2018-07-16 /pmc/articles/PMC6077508/ /pubmed/30111997 http://dx.doi.org/10.1155/2018/6872753 Text en Copyright © 2018 Sreenivasa Rao Damarla et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Damarla, Sreenivasa Rao
Komma, Rajesh
Bhatnagar, Upendra
Rajesh, Navin
Mulla, Sadik Mohmad Abdulhamid
An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
title An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
title_full An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
title_fullStr An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
title_full_unstemmed An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
title_short An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin
title_sort evaluation of the genotoxicity and subchronic oral toxicity of synthetic curcumin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077508/
https://www.ncbi.nlm.nih.gov/pubmed/30111997
http://dx.doi.org/10.1155/2018/6872753
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