Inhibition of MDM2 via Nutlin-3A: A Potential Therapeutic Approach for Pleural Mesotheliomas with MDM2-Induced Inactivation of Wild-Type P53

Previously, our group demonstrated that nuclear expression of E3 ubiquitin ligase (MDM2) in malignant pleural mesothelioma (MPM) is significantly associated with decreased overall survival. A possible explanation may be that overexpression of MDM2 leads to a proteasomal degradation of TP53 that even...

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Detalles Bibliográficos
Autores principales: Walter, Robert F. H., Werner, Robert, Wessolly, Michael, Mairinger, Elena, Borchert, Sabrina, Schmeller, Jan, Kollmeier, Jens, Mairinger, Thomas, Hager, Thomas, Bankfalvi, Agnes, Christoph, Daniel C., Eberhardt, Wilfried E. E., Plönes, Till, Aigner, Clemens, Schmid, Kurt W., Wohlschlaeger, Jeremias, Mairinger, Fabian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077509/
https://www.ncbi.nlm.nih.gov/pubmed/30112000
http://dx.doi.org/10.1155/2018/1986982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077509/
https://www.ncbi.nlm.nih.gov/pubmed/30112000
http://dx.doi.org/10.1155/2018/1986982

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