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Applications of Click Chemistry in the Development of HIV Protease Inhibitors
Acquired Immunodeficiency Syndrome (AIDS) has been devastating for millions of people around the world. Inhibition of the human immunodeficiency virus (HIV) protease is among the most important approaches for the therapeutic intervention in HIV infection. Since the discovery of the HIV-1 protease, t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077553/ https://www.ncbi.nlm.nih.gov/pubmed/30112207 http://dx.doi.org/10.1155/2018/2946730 |
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author | Mudgal, Mukesh M. Birudukota, Nagaraju Doke, Mayur A. |
author_facet | Mudgal, Mukesh M. Birudukota, Nagaraju Doke, Mayur A. |
author_sort | Mudgal, Mukesh M. |
collection | PubMed |
description | Acquired Immunodeficiency Syndrome (AIDS) has been devastating for millions of people around the world. Inhibition of the human immunodeficiency virus (HIV) protease is among the most important approaches for the therapeutic intervention in HIV infection. Since the discovery of the HIV-1 protease, this enzyme has been considered as a key target for the inhibition of viral replication. A large body of research has been done to develop an effective HIV-1 protease inhibitor. There are to date 10 HIV-1 protease inhibitor drugs approved by the Food and Drug Administration (FDA) that have improved the survival and quality of life of HIV infected people. These drugs are prescribed in combination with the reverse transcriptase inhibitors, which is referred to as highly active antiretroviral therapy (HAART). The HIV-1 protease inhibitors play a vital role in HAART. The applications of click chemistry are dispersing in the field of drug discovery. Recently, click chemistry has captured a lot of attention and has become a powerful tool for the synthesis of medicinal skeletons in the discovery of anti-HIV drugs. Click reaction is a well-known method for making carbon−heteroatom−carbon bonds. Click reactions are popular because they are wide in scope, of high yielding, quick to perform, and easy to purify. In this review, we outlined current approaches towards the development of HIV-1 protease inhibitors employing click chemistry. |
format | Online Article Text |
id | pubmed-6077553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60775532018-08-15 Applications of Click Chemistry in the Development of HIV Protease Inhibitors Mudgal, Mukesh M. Birudukota, Nagaraju Doke, Mayur A. Int J Med Chem Review Article Acquired Immunodeficiency Syndrome (AIDS) has been devastating for millions of people around the world. Inhibition of the human immunodeficiency virus (HIV) protease is among the most important approaches for the therapeutic intervention in HIV infection. Since the discovery of the HIV-1 protease, this enzyme has been considered as a key target for the inhibition of viral replication. A large body of research has been done to develop an effective HIV-1 protease inhibitor. There are to date 10 HIV-1 protease inhibitor drugs approved by the Food and Drug Administration (FDA) that have improved the survival and quality of life of HIV infected people. These drugs are prescribed in combination with the reverse transcriptase inhibitors, which is referred to as highly active antiretroviral therapy (HAART). The HIV-1 protease inhibitors play a vital role in HAART. The applications of click chemistry are dispersing in the field of drug discovery. Recently, click chemistry has captured a lot of attention and has become a powerful tool for the synthesis of medicinal skeletons in the discovery of anti-HIV drugs. Click reaction is a well-known method for making carbon−heteroatom−carbon bonds. Click reactions are popular because they are wide in scope, of high yielding, quick to perform, and easy to purify. In this review, we outlined current approaches towards the development of HIV-1 protease inhibitors employing click chemistry. Hindawi 2018-07-19 /pmc/articles/PMC6077553/ /pubmed/30112207 http://dx.doi.org/10.1155/2018/2946730 Text en Copyright © 2018 Mukesh M. Mudgal et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mudgal, Mukesh M. Birudukota, Nagaraju Doke, Mayur A. Applications of Click Chemistry in the Development of HIV Protease Inhibitors |
title | Applications of Click Chemistry in the Development of HIV Protease Inhibitors |
title_full | Applications of Click Chemistry in the Development of HIV Protease Inhibitors |
title_fullStr | Applications of Click Chemistry in the Development of HIV Protease Inhibitors |
title_full_unstemmed | Applications of Click Chemistry in the Development of HIV Protease Inhibitors |
title_short | Applications of Click Chemistry in the Development of HIV Protease Inhibitors |
title_sort | applications of click chemistry in the development of hiv protease inhibitors |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077553/ https://www.ncbi.nlm.nih.gov/pubmed/30112207 http://dx.doi.org/10.1155/2018/2946730 |
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