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Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats

Alteration of dopamine (DA) and noradrenaline (NA) contributes to cognitive function. Acupuncture has been shown to affect DA and NA in chronic cerebral hypoperfusion (CCH) rats. However, the effect of acupuncture on DA-β-hydroxylase (DBH), the biosynthetic enzyme of NA, remains unknown. In CCH rats...

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Autores principales: Xiao, Ling-Yong, Yang, Jing-Wen, Wang, Xue-Rui, Ye, Yang, Yang, Na-Na, Yan, Chao-Qun, Liu, Cun-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077593/
https://www.ncbi.nlm.nih.gov/pubmed/30112399
http://dx.doi.org/10.1155/2018/5423961
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author Xiao, Ling-Yong
Yang, Jing-Wen
Wang, Xue-Rui
Ye, Yang
Yang, Na-Na
Yan, Chao-Qun
Liu, Cun-Zhi
author_facet Xiao, Ling-Yong
Yang, Jing-Wen
Wang, Xue-Rui
Ye, Yang
Yang, Na-Na
Yan, Chao-Qun
Liu, Cun-Zhi
author_sort Xiao, Ling-Yong
collection PubMed
description Alteration of dopamine (DA) and noradrenaline (NA) contributes to cognitive function. Acupuncture has been shown to affect DA and NA in chronic cerebral hypoperfusion (CCH) rats. However, the effect of acupuncture on DA-β-hydroxylase (DBH), the biosynthetic enzyme of NA, remains unknown. In CCH rats we established chronic hypoperfusion by bilateral common carotid artery occlusion (two-vessel occlusion, 2VO) and treated them with acupuncture. Acupuncture displayed beneficial effects on hippocampus-dependent memory impairments, including nonspatial and spatial memory. That is also reflected in hippocampus long-term-potentiation (LTP). Moreover, DBH expression in the hippocampus and DBH activity in cerebrospinal fluid were upregulated after acupuncture treatment. In conclusion, these in vivo findings suggest that acupuncture exerts a therapeutic effect on hippocampus-dependent memory and hippocampus LTP in CCH rats, which may be partially related to the modulation of DBH in the hippocampus.
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spelling pubmed-60775932018-08-15 Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats Xiao, Ling-Yong Yang, Jing-Wen Wang, Xue-Rui Ye, Yang Yang, Na-Na Yan, Chao-Qun Liu, Cun-Zhi Biomed Res Int Research Article Alteration of dopamine (DA) and noradrenaline (NA) contributes to cognitive function. Acupuncture has been shown to affect DA and NA in chronic cerebral hypoperfusion (CCH) rats. However, the effect of acupuncture on DA-β-hydroxylase (DBH), the biosynthetic enzyme of NA, remains unknown. In CCH rats we established chronic hypoperfusion by bilateral common carotid artery occlusion (two-vessel occlusion, 2VO) and treated them with acupuncture. Acupuncture displayed beneficial effects on hippocampus-dependent memory impairments, including nonspatial and spatial memory. That is also reflected in hippocampus long-term-potentiation (LTP). Moreover, DBH expression in the hippocampus and DBH activity in cerebrospinal fluid were upregulated after acupuncture treatment. In conclusion, these in vivo findings suggest that acupuncture exerts a therapeutic effect on hippocampus-dependent memory and hippocampus LTP in CCH rats, which may be partially related to the modulation of DBH in the hippocampus. Hindawi 2018-07-12 /pmc/articles/PMC6077593/ /pubmed/30112399 http://dx.doi.org/10.1155/2018/5423961 Text en Copyright © 2018 Ling-Yong Xiao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xiao, Ling-Yong
Yang, Jing-Wen
Wang, Xue-Rui
Ye, Yang
Yang, Na-Na
Yan, Chao-Qun
Liu, Cun-Zhi
Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats
title Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats
title_full Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats
title_fullStr Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats
title_full_unstemmed Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats
title_short Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats
title_sort acupuncture rescues cognitive impairment and upregulates dopamine-β-hydroxylase expression in chronic cerebral hypoperfusion rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077593/
https://www.ncbi.nlm.nih.gov/pubmed/30112399
http://dx.doi.org/10.1155/2018/5423961
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