Cargando…

Exploring the Therapeutic Ability of Fenugreek against Type 2 Diabetes and Breast Cancer Employing Molecular Docking and Molecular Dynamics Simulations

Fenugreek (Trigonella foenum-graecum) is used as a spice throughout the world. It is known for its medicinal properties such as antidiabetic, anticarcinogenic, and immunological activities. The present study shows the properties and the nutritional quality of fenugreek seed extract and focuses on sc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rampogu, Shailima, Parameswaran, Saravanan, Lemuel, Mary Rampogu, Lee, Keun Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077604/ https://www.ncbi.nlm.nih.gov/pubmed/30108647 http://dx.doi.org/10.1155/2018/1943203

Ejemplares similares

Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism
por: Rampogu, Shailima, et al.
Publicado: (2016)

Exploration for novel inhibitors showing back-to-front approach against VEGFR-2 kinase domain (4AG8) employing molecular docking mechanism and molecular dynamics simulations
por: Rampogu, Shailima, et al.
Publicado: (2018)

Correction to: Exploration for novel inhibitors showing back-to-front approach against VEGFR-2 kinase domain (4AG8) employing molecular docking mechanism and molecular dynamics simulations
por: Rampogu, Shailima, et al.
Publicado: (2019)

Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation
por: Parate, Shraddha, et al.
Publicado: (2021)

Molecular Docking and Molecular Dynamics Simulations Discover Curcumin Analogue as a Plausible Dual Inhibitor for SARS-CoV-2
por: Rampogu, Shailima, et al.
Publicado: (2022)

Pharmacophore Modelling-Based Drug Repurposing Approaches for SARS-CoV-2 Therapeutics
por: Rampogu, Shailima, et al.
Publicado: (2021)

Discovery of Small Molecules That Target Vascular Endothelial Growth Factor Receptor-2 Signalling Pathway Employing Molecular Modelling Studies
por: Rampogu, Shailima, et al.
Publicado: (2019)

Ginger (Zingiber officinale) phytochemicals—gingerenone-A and shogaol inhibit SaHPPK: molecular docking, molecular dynamics simulations and in vitro approaches
por: Rampogu, Shailima, et al.
Publicado: (2018)

Sulfonanilide Derivatives in Identifying Novel Aromatase Inhibitors by Applying Docking, Virtual Screening, and MD Simulations Studies
por: Rampogu, Shailima, et al.
Publicado: (2017)

Natural Compound Modulates the Cervical Cancer Microenvironment—A Pharmacophore Guided Molecular Modelling Approaches
por: Rampogu, Shailima, et al.
Publicado: (2018)

Explicit molecular dynamics simulation studies to discover novel natural compound analogues as Mycobacterium tuberculosis inhibitors
por: Rampogu, Shailima, et al.
Publicado: (2023)

An overview on monkeypox virus: Pathogenesis, transmission, host interaction and therapeutics
por: Rampogu, Shailima, et al.
Publicado: (2023)

Role of quassinoids as potential antimalarial agents: An in silico approach
por: Rampogu, Shailima
Publicado: (2015)

Discovery of Lonafarnib-Like Compounds: Pharmacophore Modeling and Molecular Dynamics Studies
por: Rampogu, Shailima, et al.
Publicado: (2020)

Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase
por: Kulkarni, Apoorva M., et al.
Publicado: (2021)

Role of breast cancer inhibitors on diabetes mellitus– an in silico approach
por: Rampogu, Shailima DV
Publicado: (2015)

Unravelling the therapeutic potential of marine drugs as SARS-CoV-2 inhibitors: An insight from essential dynamics and free energy landscape
por: Rampogu, Shailima, et al.
Publicado: (2021)

Marine-Derived Natural Products as ATP-Competitive mTOR Kinase Inhibitors for Cancer Therapeutics
por: Parate, Shraddha, et al.
Publicado: (2021)

Repurposing and computational design of PARP inhibitors as SARS-CoV-2 inhibitors
por: Rampogu, Shailima, et al.
Publicado: (2023)

Discovery of Non-Peptidic Compounds against Chagas Disease Applying Pharmacophore Guided Molecular Modelling Approaches
por: Rampogu, Shailima, et al.
Publicado: (2018)

Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer’s Disease
por: Son, Minky, et al.
Publicado: (2019)

Computational Simulations Identify Pyrrolidine-2,3-Dione Derivatives as Novel Inhibitors of Cdk5/p25 Complex to Attenuate Alzheimer’s Pathology
por: Zeb, Amir, et al.
Publicado: (2019)

Integration of molecular docking, molecular dynamics and network pharmacology to explore the multi‐target pharmacology of fenugreek against diabetes
por: Luo, Wenfeng, et al.
Publicado: (2023)

Computational Approaches to Discover Novel Natural Compounds for SARS‐CoV‐2 Therapeutics
por: Rampogu, Shailima, et al.
Publicado: (2021)

In Silico Study Probes Potential Inhibitors of Human Dihydrofolate Reductase for Cancer Therapeutics
por: Rana, Rabia Mukhtar, et al.
Publicado: (2019)

Curcumin Chalcone Derivatives Database (CCDD): a Python framework for natural compound derivatives database
por: Rampogu, Shailima, et al.
Publicado: (2023)

Discovery of Potential Plant-Derived Peptide Deformylase (PDF) Inhibitors for Multidrug-Resistant Bacteria Using Computational Studies
por: Rampogu, Shailima, et al.
Publicado: (2018)

In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics
por: Rana, Rabia Mukhtar, et al.
Publicado: (2020)

Pharmacotherapeutics and Molecular Mechanism of Phytochemicals in Alleviating Hormone-Responsive Breast Cancer
por: Rampogu, Shailima, et al.
Publicado: (2019)

New compounds identified through in silico approaches reduce the α-synuclein expression by inhibiting prolyl oligopeptidase in vitro
por: Kumar, Raj, et al.
Publicado: (2017)

Computational Exploration for Lead Compounds That Can Reverse the Nuclear Morphology in Progeria
por: Rampogu, Shailima, et al.
Publicado: (2017)

Novel Butein Derivatives Repress DDX3 Expression by Inhibiting PI3K/AKT Signaling Pathway in MCF-7 and MDA-MB-231 Cell Lines
por: Rampogu, Shailima, et al.
Publicado: (2021)

CBPDdb: a curated database of compounds derived from Coumarin–Benzothiazole–Pyrazole
por: Rampogu, Shailima, et al.
Publicado: (2023)

Transcriptome analysis of sinensetin-treated liver cancer cells guided by biological network analysis
por: Kim, Seong Min, et al.
Publicado: (2021)

A Computational Approach with Biological Evaluation: Combinatorial Treatment of Curcumin and Exemestane Synergistically Regulates DDX3 Expression in Cancer Cell Lines
por: Rampogu, Shailima, et al.
Publicado: (2020)

Sinensetin Induces Autophagic Cell Death through p53-Related AMPK/mTOR Signaling in Hepatocellular Carcinoma HepG2 Cells
por: Kim, Seong Min, et al.
Publicado: (2020)

Exploring the therapeutic mechanisms of Gleditsiae Spina acting on pancreatic cancer via network pharmacology, molecular docking and molecular dynamics simulation
por: Duan, Hongtao, et al.
Publicado: (2023)

Computational Simulations Highlight the IL2Rα Binding Potential of Polyphenol Stilbenes from Fenugreek
por: Kulkarni, Apoorva M., et al.
Publicado: (2022)

Exploration of Flavonoids as Lead Compounds against Ewing Sarcoma through Molecular Docking, Pharmacogenomics Analysis, and Molecular Dynamics Simulations
por: Yasir, Muhammad, et al.
Publicado: (2023)

Ethanolic Fenugreek Extract: Its Molecular Mechanisms against Skin Aging and the Enhanced Functions by Nanoencapsulation
por: Eaknai, Waleewan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c0ooufjnvvmtnf1hr81f3pa5i2