Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER(+)) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node in a previously unappreciated negative feedback loop that limits the eff...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Tengfei, Li, Wei, Wang, Xiaoqing, Xu, Han, Yang, Jixin, Wu, Qiu, Huang, Ying, Geradts, Joseph, Jiang, Peng, Fei, Teng, Chi, David, Zang, Chongzhi, Liao, Qi, Rennhack, Jonathan, Andrechek, Eran, Li, Nanlin, Detre, Simone, Dowsett, Mitchell, Jeselsohn, Rinath M., Liu, X. Shirley, Brown, Myles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077722/
https://www.ncbi.nlm.nih.gov/pubmed/29987050
http://dx.doi.org/10.1073/pnas.1722617115

Ejemplares similares

Ejemplares similares