Cargando…
Comparative evaluation of anti-angiogenic effects of noscapine derivatives
Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumor progression. Synthetic derivatives of anti-cancer compound, noscapine (an opium alkaloid) such as Cl-noscapine, Br-noscapine and Folate-noscapine along with two of the reference compounds, TNP-470 and pa...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Biomedical Informatics
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077819/ https://www.ncbi.nlm.nih.gov/pubmed/30108421 http://dx.doi.org/10.6026/97320630014236 |
_version_ | 1783344985956941824 |
---|---|
author | Meher, Rajesh K. Naik, Manas Ranjan Bastia, Banajit Naik, Pradeep K. |
author_facet | Meher, Rajesh K. Naik, Manas Ranjan Bastia, Banajit Naik, Pradeep K. |
author_sort | Meher, Rajesh K. |
collection | PubMed |
description | Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumor progression. Synthetic derivatives of anti-cancer compound, noscapine (an opium alkaloid) such as Cl-noscapine, Br-noscapine and Folate-noscapine along with two of the reference compounds, TNP-470 and paclitaxel were examined for anti-angiogenic activities by using human umbilical vein endothelial cells (HUVECs). The noscapine derivatives showed anti-angiogenic activity albeit at high concentration compared to the reference compounds. All the tested compounds inhibited angiogenesis in a dose-dependent manner; the drug concentration causing 50% inhibition of cell survival was 11.87 μM for Cl-noscapine, 6.9 μM for Br-noscapine and 6.79 μM for folate-noscapine. Besides, all the noscapine derivatives significantly inhibited cord formation (IC50 for Cl-noscapine is 50.76 μM, for Br-noscapine is 90.08 μM and for folate-noscapine is 18.44 μM) as well as migration and invasion (IC50 value of Cl-noscapine is 28.01 μM, for Br-noscapine is 19.78 μM and for folate-noscapine is 10.76 μM) of endothelial cells. Based on these results, we speculated that the inhibitory effects on human endothelial cell proliferation of noscapine derivatives might be important for anti-angiogenesis. |
format | Online Article Text |
id | pubmed-6077819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-60778192018-08-14 Comparative evaluation of anti-angiogenic effects of noscapine derivatives Meher, Rajesh K. Naik, Manas Ranjan Bastia, Banajit Naik, Pradeep K. Bioinformation Hypothesis Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumor progression. Synthetic derivatives of anti-cancer compound, noscapine (an opium alkaloid) such as Cl-noscapine, Br-noscapine and Folate-noscapine along with two of the reference compounds, TNP-470 and paclitaxel were examined for anti-angiogenic activities by using human umbilical vein endothelial cells (HUVECs). The noscapine derivatives showed anti-angiogenic activity albeit at high concentration compared to the reference compounds. All the tested compounds inhibited angiogenesis in a dose-dependent manner; the drug concentration causing 50% inhibition of cell survival was 11.87 μM for Cl-noscapine, 6.9 μM for Br-noscapine and 6.79 μM for folate-noscapine. Besides, all the noscapine derivatives significantly inhibited cord formation (IC50 for Cl-noscapine is 50.76 μM, for Br-noscapine is 90.08 μM and for folate-noscapine is 18.44 μM) as well as migration and invasion (IC50 value of Cl-noscapine is 28.01 μM, for Br-noscapine is 19.78 μM and for folate-noscapine is 10.76 μM) of endothelial cells. Based on these results, we speculated that the inhibitory effects on human endothelial cell proliferation of noscapine derivatives might be important for anti-angiogenesis. Biomedical Informatics 2018 -05-31 /pmc/articles/PMC6077819/ /pubmed/30108421 http://dx.doi.org/10.6026/97320630014236 Text en © 2018 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Hypothesis Meher, Rajesh K. Naik, Manas Ranjan Bastia, Banajit Naik, Pradeep K. Comparative evaluation of anti-angiogenic effects of noscapine derivatives |
title | Comparative evaluation of anti-angiogenic effects of noscapine derivatives |
title_full | Comparative evaluation of anti-angiogenic effects of noscapine derivatives |
title_fullStr | Comparative evaluation of anti-angiogenic effects of noscapine derivatives |
title_full_unstemmed | Comparative evaluation of anti-angiogenic effects of noscapine derivatives |
title_short | Comparative evaluation of anti-angiogenic effects of noscapine derivatives |
title_sort | comparative evaluation of anti-angiogenic effects of noscapine derivatives |
topic | Hypothesis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077819/ https://www.ncbi.nlm.nih.gov/pubmed/30108421 http://dx.doi.org/10.6026/97320630014236 |
work_keys_str_mv | AT meherrajeshk comparativeevaluationofantiangiogeniceffectsofnoscapinederivatives AT naikmanasranjan comparativeevaluationofantiangiogeniceffectsofnoscapinederivatives AT bastiabanajit comparativeevaluationofantiangiogeniceffectsofnoscapinederivatives AT naikpradeepk comparativeevaluationofantiangiogeniceffectsofnoscapinederivatives |