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The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke
Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke, leading to increased repair and functional recovery in animal models of cerebral ischaemia. While it was initially hypothesised that cell replacement was an important mechanism of action of MSCs, focus has shift...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077926/ https://www.ncbi.nlm.nih.gov/pubmed/29768965 http://dx.doi.org/10.1177/0271678X18776802 |
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author | Cunningham, Catriona J Redondo-Castro, Elena Allan, Stuart M |
author_facet | Cunningham, Catriona J Redondo-Castro, Elena Allan, Stuart M |
author_sort | Cunningham, Catriona J |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke, leading to increased repair and functional recovery in animal models of cerebral ischaemia. While it was initially hypothesised that cell replacement was an important mechanism of action of MSCs, focus has shifted to their paracrine actions or the so called “bystander” effect. MSCs secrete a wide array of growth factors, chemokines, cytokines and extracellular vesicles, commonly referred to as the MSC secretome. There is evidence suggesting the MSC secretome can promote repair through a number of mechanisms including preventing cell apoptosis, modulating the inflammatory response and promoting endogenous repair mechanisms such as angiogenesis and neurogenesis. In this review, we will discuss the in vitro approaches currently being employed to drive the MSC secretome towards a more anti-inflammatory and regenerative phenotype. We will then examine the role of the secretome in promoting repair and improving recovery in preclinical models of cerebral ischaemia. |
format | Online Article Text |
id | pubmed-6077926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-60779262018-08-13 The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke Cunningham, Catriona J Redondo-Castro, Elena Allan, Stuart M J Cereb Blood Flow Metab Review Articles Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke, leading to increased repair and functional recovery in animal models of cerebral ischaemia. While it was initially hypothesised that cell replacement was an important mechanism of action of MSCs, focus has shifted to their paracrine actions or the so called “bystander” effect. MSCs secrete a wide array of growth factors, chemokines, cytokines and extracellular vesicles, commonly referred to as the MSC secretome. There is evidence suggesting the MSC secretome can promote repair through a number of mechanisms including preventing cell apoptosis, modulating the inflammatory response and promoting endogenous repair mechanisms such as angiogenesis and neurogenesis. In this review, we will discuss the in vitro approaches currently being employed to drive the MSC secretome towards a more anti-inflammatory and regenerative phenotype. We will then examine the role of the secretome in promoting repair and improving recovery in preclinical models of cerebral ischaemia. SAGE Publications 2018-05-17 2018-08 /pmc/articles/PMC6077926/ /pubmed/29768965 http://dx.doi.org/10.1177/0271678X18776802 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Articles Cunningham, Catriona J Redondo-Castro, Elena Allan, Stuart M The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke |
title | The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke |
title_full | The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke |
title_fullStr | The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke |
title_full_unstemmed | The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke |
title_short | The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke |
title_sort | therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077926/ https://www.ncbi.nlm.nih.gov/pubmed/29768965 http://dx.doi.org/10.1177/0271678X18776802 |
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