Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells

Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem cell compartment integrity. Normal adult stem cells have the longest telomeres in a given tissue, a property mediated by high hTERT expression and high telomerase enzymatic activity. In contrast, cance...

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Detalles Bibliográficos
Autores principales: El-Badawy, Ahmed, Ghoneim, Nehal I., Nasr, Mohamed A., Elkhenany, Hoda, Ahmed, Toka A., Ahmed, Sara M., El-Badri, Nagwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078341/
https://www.ncbi.nlm.nih.gov/pubmed/29907642
http://dx.doi.org/10.1242/bio.034181

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