Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins

Dickkopf (Dkk) family proteins are important regulators of Wnt signaling pathways, which play key roles in many essential biological processes. Here, we report the first detailed structural and dynamics study of a full-length mature Dkk protein (Dkk4, residues 19–224), including determination of the...

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Detalles Bibliográficos
Autores principales: Patel, Saleha, Barkell, Alice M., Gupta, Deepti, Strong, Sarah L., Bruton, Shaun, Muskett, Frederick W., Addis, Philip W., Renshaw, Philip S., Slocombe, Patrick M., Doyle, Carl, Clargo, Alison, Taylor, Richard J., Prosser, Christine E., Henry, Alistair J., Robinson, Martyn K., Waters, Lorna C., Holdsworth, Gill, Carr, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078440/
https://www.ncbi.nlm.nih.gov/pubmed/29925589
http://dx.doi.org/10.1074/jbc.RA118.002918

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