Cargando…

Exploiting natural regulation

Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs.

Detalles Bibliográficos
Autor principal:	Proenza, Catherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078491/ https://www.ncbi.nlm.nih.gov/pubmed/30080138 http://dx.doi.org/10.7554/eLife.39664

Ejemplares similares

The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase
por: Kawanabe, Akira, et al.
Publicado: (2018)

Filamentation modulates allosteric regulation of PRPS
por: Hu, Huan-Huan, et al.
Publicado: (2022)

Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex
por: Kasuya, Go, et al.
Publicado: (2022)

Structure of the human volume regulated anion channel
por: Kefauver, Jennifer M, et al.
Publicado: (2018)

Regulation of human mTOR complexes by DEPTOR
por: Wälchli, Matthias, et al.
Publicado: (2021)

Multivalency regulates activity in an intrinsically disordered transcription factor
por: Clark, Sarah, et al.
Publicado: (2018)

Multivalency regulates activity in an intrinsically disordered transcription factor
por: Clark, Sarah, et al.
Publicado: (2018)

Architectural principles for Hfq/Crc-mediated regulation of gene expression
por: Pei, Xue Yuan, et al.
Publicado: (2019)

Calcium-driven regulation of voltage-sensing domains in BK channels
por: Lorenzo-Ceballos, Yenisleidy, et al.
Publicado: (2019)

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents
por: Vinayagam, Deivanayagabarathy, et al.
Publicado: (2020)

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21
por: Dickson, Claire, et al.
Publicado: (2018)

Cryo-EM analysis of PIP(2) regulation in mammalian GIRK channels
por: Niu, Yiming, et al.
Publicado: (2020)

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation
por: Kolich, Ljuvica R, et al.
Publicado: (2020)

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
por: Ramakrishnan, Sathish, et al.
Publicado: (2020)

Activation of the archaeal ion channel MthK is exquisitely regulated by temperature
por: Jiang, Yihao, et al.
Publicado: (2020)

TMEM266 is a functional voltage sensor regulated by extracellular Zn(2+)
por: Papp, Ferenc, et al.
Publicado: (2019)

Mg(2+)-dependent conformational equilibria in CorA and an integrated view on transport regulation
por: Johansen, Nicolai Tidemand, et al.
Publicado: (2022)

Dynamic clustering of dynamin-amphiphysin helices regulates membrane constriction and fission coupled with GTP hydrolysis
por: Takeda, Tetsuya, et al.
Publicado: (2018)

Structure of a TRPM2 channel in complex with Ca(2+) explains unique gating regulation
por: Zhang, Zhe, et al.
Publicado: (2018)

Allosteric regulators selectively prevent Ca(2+)-feedback of Ca(V) and Na(V) channels
por: Niu, Jacqueline, et al.
Publicado: (2018)

Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation
por: Wieteska, Lukasz, et al.
Publicado: (2017)

Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation
por: Johnson, Matthew C, et al.
Publicado: (2020)

Geometry of antiparallel microtubule bundles regulates relative sliding and stalling by PRC1 and Kif4A
por: Wijeratne, Sithara, et al.
Publicado: (2018)

Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein
por: Jara, Kayla A, et al.
Publicado: (2022)

Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15
por: Mahbub, Luba, et al.
Publicado: (2023)

A new insight into RecA filament regulation by RecX from the analysis of conformation-specific interactions
por: Alekseev, Aleksandr, et al.
Publicado: (2022)

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
por: Saponaro, Andrea, et al.
Publicado: (2018)

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
por: Lauer, Janelle, et al.
Publicado: (2019)

A putative structural mechanism underlying the antithetic effect of homologous RND1 and RhoD GTPases in mammalian plexin regulation
por: Liu, Yanyan, et al.
Publicado: (2021)

ER-luminal [Ca(2+)] regulation of InsP(3) receptor gating mediated by an ER-luminal peripheral Ca(2+)-binding protein
por: Vais, Horia, et al.
Publicado: (2020)

A critical residue in the α(1)M2–M3 linker regulating mammalian GABA(A) receptor pore gating by diazepam
por: Nors, Joseph W, et al.
Publicado: (2021)

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM
por: López-Perrote, Andres, et al.
Publicado: (2020)

Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker
por: Bonazza, Klaus, et al.
Publicado: (2022)

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers
por: Moraga, Ignacio, et al.
Publicado: (2017)

Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action
por: Trajtenberg, Felipe, et al.
Publicado: (2016)

PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3
por: Chung, Ho-Ryun, et al.
Publicado: (2016)

Mechanism for nuclease regulation in RecBCD
por: Wilkinson, Martin, et al.
Publicado: (2016)

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein
por: Renner, Max, et al.
Publicado: (2016)

Dna2 nuclease-helicase structure, mechanism and regulation by Rpa
por: Zhou, Chun, et al.
Publicado: (2015)

Mechanism of allosteric regulation of β(2)-adrenergic receptor by cholesterol
por: Manna, Moutusi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ttigkcqdgg32o2rg8024f8lehu