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Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation

Cytokines and interferons initiate intracellular signaling via receptor dimerization and activation of Janus kinases (JAKs). How JAKs structurally respond to changes in receptor conformation induced by ligand binding is not known. Here, we present two crystal structures of the human JAK2 FERM and SH...

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Detalles Bibliográficos
Autores principales:	Ferrao, Ryan D, Wallweber, Heidi JA, Lupardus, Patrick J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078494/ https://www.ncbi.nlm.nih.gov/pubmed/30044226 http://dx.doi.org/10.7554/eLife.38089

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