Assisted reproductive technique outcomes in hypogonadotropic hypogonadism women

BACKGROUND AND OBJECTIVES: To evaluate the outcomes of using in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI cycle) techniques in hypogonadotropic hypogonadism (HH) women and comparing them to women with tubal factor infertility. DESIGN AND SETTINGS: Retrospective cohort study in Royan Institute, Iran. PATIENTS AND METHODS: Data from 81 HH patients treated with IVF/ICSI in the period from early 2009 until the end of 2010 were analyzed and compared with treatment results from 89 patients with tubal factor infertility. Moreover, data from the HH patients were analyzed with respect to the age factor. P value <.05 was considered statistically significant. The main outcome measures were implantation, fertilization, pregnancy, and live birth rates. RESULTS: Despite a higher fertilization rate and higher number of grade A/B embryos transferred in the tubal factor group, the implantation, pregnancy, and live birth rates were found to be similar between the 2 groups (P=.3, P=.1, P=.1, respectively). When the HH patients were evaluated according to the age factor, no significant difference was found regarding outcome parameters (P=.2). CONCLUSIONS: HH women that were treated with IVF/ICSI cycles seem to have a sound potential for pregnancy, even in advanced age patients.