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Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia
BACKGROUND: Patients with severe sickle cell anemia (SCA) have a higher potential for oxidative damage due to chronic redox imbalance in red blood cells that often leads to hemolysis, endothelial injury and recurrent vaso-occlusive episodes. This study evaluated the plasma levels of vitamins A, C an...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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King Faisal Specialist Hospital and Research Centre
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078551/ https://www.ncbi.nlm.nih.gov/pubmed/16521870 http://dx.doi.org/10.5144/0256-4947.2006.17 |
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author | Hasanato, Rana M.W. |
author_facet | Hasanato, Rana M.W. |
author_sort | Hasanato, Rana M.W. |
collection | PubMed |
description | BACKGROUND: Patients with severe sickle cell anemia (SCA) have a higher potential for oxidative damage due to chronic redox imbalance in red blood cells that often leads to hemolysis, endothelial injury and recurrent vaso-occlusive episodes. This study evaluated the plasma levels of vitamins A, C and E as indicators of antioxidant status. In addition, serum levels of zinc and copper were also estimated. PATIENTS AND METHODS: Twenty-five adult patients with severe sickle cell anemia (12 males and 13 females aged 29.72±12.94 years) and 25 matched controls were studied. Plasma levels of vitamins A, C and E were measured by HPLC technique. Serum zinc and copper levels were measured by atomic absorption spectrometry. RESULTS: There was a significant decrease in plasma levels of vitamins A, C and E and in serum levels of zinc in patients with SCA as compared with controls (P<0.0001). Serum copper levels were signficantly elevated compared with controls (P<0.0001). CONCLUSION: These findings emphasize the significant deficiencies of the antioxidant vitamins A, C and E and the trace element zinc along with the significant elevation of serum copper in patients with severe sickle cell disease. Further studies are needed to find out whether supplementation of antioxidant vitamins and zinc may ameliorate some sickle cell disease complications. |
format | Online Article Text |
id | pubmed-6078551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | King Faisal Specialist Hospital and Research Centre |
record_format | MEDLINE/PubMed |
spelling | pubmed-60785512018-09-21 Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia Hasanato, Rana M.W. Ann Saudi Med Original Article BACKGROUND: Patients with severe sickle cell anemia (SCA) have a higher potential for oxidative damage due to chronic redox imbalance in red blood cells that often leads to hemolysis, endothelial injury and recurrent vaso-occlusive episodes. This study evaluated the plasma levels of vitamins A, C and E as indicators of antioxidant status. In addition, serum levels of zinc and copper were also estimated. PATIENTS AND METHODS: Twenty-five adult patients with severe sickle cell anemia (12 males and 13 females aged 29.72±12.94 years) and 25 matched controls were studied. Plasma levels of vitamins A, C and E were measured by HPLC technique. Serum zinc and copper levels were measured by atomic absorption spectrometry. RESULTS: There was a significant decrease in plasma levels of vitamins A, C and E and in serum levels of zinc in patients with SCA as compared with controls (P<0.0001). Serum copper levels were signficantly elevated compared with controls (P<0.0001). CONCLUSION: These findings emphasize the significant deficiencies of the antioxidant vitamins A, C and E and the trace element zinc along with the significant elevation of serum copper in patients with severe sickle cell disease. Further studies are needed to find out whether supplementation of antioxidant vitamins and zinc may ameliorate some sickle cell disease complications. King Faisal Specialist Hospital and Research Centre 2006 /pmc/articles/PMC6078551/ /pubmed/16521870 http://dx.doi.org/10.5144/0256-4947.2006.17 Text en Copyright © 2006, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Hasanato, Rana M.W. Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia |
title | Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia |
title_full | Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia |
title_fullStr | Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia |
title_full_unstemmed | Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia |
title_short | Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia |
title_sort | zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078551/ https://www.ncbi.nlm.nih.gov/pubmed/16521870 http://dx.doi.org/10.5144/0256-4947.2006.17 |
work_keys_str_mv | AT hasanatoranamw zincandantioxidantvitamindeficiencyinpatientswithseveresicklecellanemia |