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Celiac disease presenting as rickets in Saudi children

BACKGROUND AND OBJECTIVES: Rickets is commonly seen as a sign of malabsorption like celiac disease if it is not treated appropriately with vitamin D and calcium supplements. The aim of this study was to examine the frequency of diagnosis of celiac disease among children with unexplained rickets in S...

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Autores principales: Assiri, Asaad, Saeed, Anjum, Al Sarkhy, Ahmed, El Mouzan, Mohammed Issa, El Matary, Wael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078568/
https://www.ncbi.nlm.nih.gov/pubmed/23458941
http://dx.doi.org/10.5144/0256-4947.2013.49
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author Assiri, Asaad
Saeed, Anjum
Al Sarkhy, Ahmed
El Mouzan, Mohammed Issa
El Matary, Wael
author_facet Assiri, Asaad
Saeed, Anjum
Al Sarkhy, Ahmed
El Mouzan, Mohammed Issa
El Matary, Wael
author_sort Assiri, Asaad
collection PubMed
description BACKGROUND AND OBJECTIVES: Rickets is commonly seen as a sign of malabsorption like celiac disease if it is not treated appropriately with vitamin D and calcium supplements. The aim of this study was to examine the frequency of diagnosis of celiac disease among children with unexplained rickets in Saudi children at a tertiary hospital setting. DESIGN AND SETTING: Retrospective review of records of patients referred over 10 years to a pediatric gastroenterology and hepatology unit. PATIENTS AND METHODS: The study included all patients referred for evaluation of unexplained rickets and osteomalacia and screened for celiac disease. The diagnosis of rickets was made on the basis of history, physical examination, biochemical and radiological investigations. The diagnosis of celiac disease was made based on the ESPGHAN (European Society for Pediatric Gastroenterology, Hepatology, and Nutrition) criteria. RESULTS: Twenty-six children with a mean (SD) age of 9.5 (4.6) years (5 males, range 1–15 years) were referred for evaluation of unexplained rickets and were screened for celiac disease. The diagnosis of celiac disease based on small bowel biopsy findings was confirmed in 10 (38.4%) patients with rickets. Serological markers for celiac disease including antiendomyseal antibodies and antitissue transglutaminase antibodies were positive in all ten children. CONCLUSION: Rickets is not an uncommon presentation of celiac disease in Saudi children and pediatricians should consider celiac disease as an underlying cause for rickets.
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spelling pubmed-60785682018-09-21 Celiac disease presenting as rickets in Saudi children Assiri, Asaad Saeed, Anjum Al Sarkhy, Ahmed El Mouzan, Mohammed Issa El Matary, Wael Ann Saudi Med Original Article BACKGROUND AND OBJECTIVES: Rickets is commonly seen as a sign of malabsorption like celiac disease if it is not treated appropriately with vitamin D and calcium supplements. The aim of this study was to examine the frequency of diagnosis of celiac disease among children with unexplained rickets in Saudi children at a tertiary hospital setting. DESIGN AND SETTING: Retrospective review of records of patients referred over 10 years to a pediatric gastroenterology and hepatology unit. PATIENTS AND METHODS: The study included all patients referred for evaluation of unexplained rickets and osteomalacia and screened for celiac disease. The diagnosis of rickets was made on the basis of history, physical examination, biochemical and radiological investigations. The diagnosis of celiac disease was made based on the ESPGHAN (European Society for Pediatric Gastroenterology, Hepatology, and Nutrition) criteria. RESULTS: Twenty-six children with a mean (SD) age of 9.5 (4.6) years (5 males, range 1–15 years) were referred for evaluation of unexplained rickets and were screened for celiac disease. The diagnosis of celiac disease based on small bowel biopsy findings was confirmed in 10 (38.4%) patients with rickets. Serological markers for celiac disease including antiendomyseal antibodies and antitissue transglutaminase antibodies were positive in all ten children. CONCLUSION: Rickets is not an uncommon presentation of celiac disease in Saudi children and pediatricians should consider celiac disease as an underlying cause for rickets. King Faisal Specialist Hospital and Research Centre 2013 /pmc/articles/PMC6078568/ /pubmed/23458941 http://dx.doi.org/10.5144/0256-4947.2013.49 Text en Copyright © 2013, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Assiri, Asaad
Saeed, Anjum
Al Sarkhy, Ahmed
El Mouzan, Mohammed Issa
El Matary, Wael
Celiac disease presenting as rickets in Saudi children
title Celiac disease presenting as rickets in Saudi children
title_full Celiac disease presenting as rickets in Saudi children
title_fullStr Celiac disease presenting as rickets in Saudi children
title_full_unstemmed Celiac disease presenting as rickets in Saudi children
title_short Celiac disease presenting as rickets in Saudi children
title_sort celiac disease presenting as rickets in saudi children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078568/
https://www.ncbi.nlm.nih.gov/pubmed/23458941
http://dx.doi.org/10.5144/0256-4947.2013.49
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