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Gleason grading of prostate cancer in needle core biopsies: a comparison of general and urologic pathologists

BACKGROUND AND OBJECTIVES: The Gleason grading of prostate carcinoma (PCa) in needle core biopsies is a major determinant used in management planning. The objective of this study was to evaluate the concordance between general pathologists Gleason grading and that of a urologic pathologist in our co...

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Autores principales: Al-Maghrabi, Jaudah Ahmed, Bakshi, Nasir A., Farsi, Hasan M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078572/
https://www.ncbi.nlm.nih.gov/pubmed/23458939
http://dx.doi.org/10.5144/0256-4947.2013.40
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author Al-Maghrabi, Jaudah Ahmed
Bakshi, Nasir A.
Farsi, Hasan M.A.
author_facet Al-Maghrabi, Jaudah Ahmed
Bakshi, Nasir A.
Farsi, Hasan M.A.
author_sort Al-Maghrabi, Jaudah Ahmed
collection PubMed
description BACKGROUND AND OBJECTIVES: The Gleason grading of prostate carcinoma (PCa) in needle core biopsies is a major determinant used in management planning. The objective of this study was to evaluate the concordance between general pathologists Gleason grading and that of a urologic pathologist in our community. DESIGN AND SETTING: Retrospective review conducted at three tertiary care hospitals in Jeddah and Riyadh for all prostatic biopsies with carcinoma from January 2002 to January 2011. METHODS: Gleason scores assigned by the original pathologist were compared with that of the reviewing urologic pathologists. Biopsies were originally obtained and diagnosed at different referring hospitals and independent laboratories. The kappa test was used to evaluate agreement between the original and review scores. RESULTS: For 212 biopsies the exact concordance of the Gleason score assigned by the original pathologist and the reviewer was 38.7% (82/212). However, when grouped into the main four-score categories of 2–4, 5–6, 7, and 8 or greater, disagreement was noted in 88 (41.5%) biopsies; 87 were upgraded and 1 was downgraded on review. When grouped into two-score categories of low grade (≤6) and high grade (≥7), disagreement was noted in 32 (15%) of the biopsies. CONCLUSION: Gleason grade score shows that there was only slight to fair agreement between outside and review scoring (kappa=0.43). When using only low versus high grade categorization, there was good agreement (kappa=0.69). Almost all of the cases with score disagreement were upgraded on review.
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spelling pubmed-60785722018-09-21 Gleason grading of prostate cancer in needle core biopsies: a comparison of general and urologic pathologists Al-Maghrabi, Jaudah Ahmed Bakshi, Nasir A. Farsi, Hasan M.A. Ann Saudi Med Original Article BACKGROUND AND OBJECTIVES: The Gleason grading of prostate carcinoma (PCa) in needle core biopsies is a major determinant used in management planning. The objective of this study was to evaluate the concordance between general pathologists Gleason grading and that of a urologic pathologist in our community. DESIGN AND SETTING: Retrospective review conducted at three tertiary care hospitals in Jeddah and Riyadh for all prostatic biopsies with carcinoma from January 2002 to January 2011. METHODS: Gleason scores assigned by the original pathologist were compared with that of the reviewing urologic pathologists. Biopsies were originally obtained and diagnosed at different referring hospitals and independent laboratories. The kappa test was used to evaluate agreement between the original and review scores. RESULTS: For 212 biopsies the exact concordance of the Gleason score assigned by the original pathologist and the reviewer was 38.7% (82/212). However, when grouped into the main four-score categories of 2–4, 5–6, 7, and 8 or greater, disagreement was noted in 88 (41.5%) biopsies; 87 were upgraded and 1 was downgraded on review. When grouped into two-score categories of low grade (≤6) and high grade (≥7), disagreement was noted in 32 (15%) of the biopsies. CONCLUSION: Gleason grade score shows that there was only slight to fair agreement between outside and review scoring (kappa=0.43). When using only low versus high grade categorization, there was good agreement (kappa=0.69). Almost all of the cases with score disagreement were upgraded on review. King Faisal Specialist Hospital and Research Centre 2013 /pmc/articles/PMC6078572/ /pubmed/23458939 http://dx.doi.org/10.5144/0256-4947.2013.40 Text en Copyright © 2013, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Al-Maghrabi, Jaudah Ahmed
Bakshi, Nasir A.
Farsi, Hasan M.A.
Gleason grading of prostate cancer in needle core biopsies: a comparison of general and urologic pathologists
title Gleason grading of prostate cancer in needle core biopsies: a comparison of general and urologic pathologists
title_full Gleason grading of prostate cancer in needle core biopsies: a comparison of general and urologic pathologists
title_fullStr Gleason grading of prostate cancer in needle core biopsies: a comparison of general and urologic pathologists
title_full_unstemmed Gleason grading of prostate cancer in needle core biopsies: a comparison of general and urologic pathologists
title_short Gleason grading of prostate cancer in needle core biopsies: a comparison of general and urologic pathologists
title_sort gleason grading of prostate cancer in needle core biopsies: a comparison of general and urologic pathologists
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078572/
https://www.ncbi.nlm.nih.gov/pubmed/23458939
http://dx.doi.org/10.5144/0256-4947.2013.40
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