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No association between MGP rs1800802 polymorphism and stenosis of the coronary artery

BACKGROUND AND OBJECTIVES: Matrix Gla protein (MGP) was originally isolated from bone but it is known to be expressed in several tissues including kidney, lung, heart, cartilage and vascular smooth muscle cells (VSMC) of the blood vessel wall. Since it inhibits calcification in subendothelial space...

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Autores principales: Roustazadeh, Abazar, Najafi, Mohammad, Amirfarhangi, Abdollah, Nourmohammadi, Issa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078625/
https://www.ncbi.nlm.nih.gov/pubmed/23563003
http://dx.doi.org/10.5144/0256-4947.2013.149
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author Roustazadeh, Abazar
Najafi, Mohammad
Amirfarhangi, Abdollah
Nourmohammadi, Issa
author_facet Roustazadeh, Abazar
Najafi, Mohammad
Amirfarhangi, Abdollah
Nourmohammadi, Issa
author_sort Roustazadeh, Abazar
collection PubMed
description BACKGROUND AND OBJECTIVES: Matrix Gla protein (MGP) was originally isolated from bone but it is known to be expressed in several tissues including kidney, lung, heart, cartilage and vascular smooth muscle cells (VSMC) of the blood vessel wall. Since it inhibits calcification in subendothelial space of vessels thus, we evaluated the association of rs1800802(T>C) polymorphism and stenosis of the coronary artery. DESIGN AND SETTING: Cross-sectional case-control. SUBJECTS AND METHODS: One hundred eighty two subjects recruited on the basis of study protocol from who underwent coronary angiography. The controls (n=70) had normal coronary arteries (up to 5% stenosis). The patients (n=112) subdivided into three subgroups; single-vessel disease (SVD), two-vessel disease (2VD) and three-vessel disease (3VD) based on the number of stenosed coronary vessels (at least 50% stenosis). rs1800802 (T>C) polymorphism was determined by PCR-RFLP technique. RESULTS: Genotype distribution was not significant between control and patient groups. In addition, there were no significant differences between rs1800802 (T>C) frequency and gender (P=.092), and also patient subgroups (one-, two- and three vessel disease) (P=.840). CONCLUSION: We concluded that rs1800802 (T>C) polymorphism within the MGP promoter is not related to stenosis of the coronary artery.
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spelling pubmed-60786252018-09-21 No association between MGP rs1800802 polymorphism and stenosis of the coronary artery Roustazadeh, Abazar Najafi, Mohammad Amirfarhangi, Abdollah Nourmohammadi, Issa Ann Saudi Med Original Article BACKGROUND AND OBJECTIVES: Matrix Gla protein (MGP) was originally isolated from bone but it is known to be expressed in several tissues including kidney, lung, heart, cartilage and vascular smooth muscle cells (VSMC) of the blood vessel wall. Since it inhibits calcification in subendothelial space of vessels thus, we evaluated the association of rs1800802(T>C) polymorphism and stenosis of the coronary artery. DESIGN AND SETTING: Cross-sectional case-control. SUBJECTS AND METHODS: One hundred eighty two subjects recruited on the basis of study protocol from who underwent coronary angiography. The controls (n=70) had normal coronary arteries (up to 5% stenosis). The patients (n=112) subdivided into three subgroups; single-vessel disease (SVD), two-vessel disease (2VD) and three-vessel disease (3VD) based on the number of stenosed coronary vessels (at least 50% stenosis). rs1800802 (T>C) polymorphism was determined by PCR-RFLP technique. RESULTS: Genotype distribution was not significant between control and patient groups. In addition, there were no significant differences between rs1800802 (T>C) frequency and gender (P=.092), and also patient subgroups (one-, two- and three vessel disease) (P=.840). CONCLUSION: We concluded that rs1800802 (T>C) polymorphism within the MGP promoter is not related to stenosis of the coronary artery. King Faisal Specialist Hospital and Research Centre 2013 /pmc/articles/PMC6078625/ /pubmed/23563003 http://dx.doi.org/10.5144/0256-4947.2013.149 Text en Copyright © 2013, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Roustazadeh, Abazar
Najafi, Mohammad
Amirfarhangi, Abdollah
Nourmohammadi, Issa
No association between MGP rs1800802 polymorphism and stenosis of the coronary artery
title No association between MGP rs1800802 polymorphism and stenosis of the coronary artery
title_full No association between MGP rs1800802 polymorphism and stenosis of the coronary artery
title_fullStr No association between MGP rs1800802 polymorphism and stenosis of the coronary artery
title_full_unstemmed No association between MGP rs1800802 polymorphism and stenosis of the coronary artery
title_short No association between MGP rs1800802 polymorphism and stenosis of the coronary artery
title_sort no association between mgp rs1800802 polymorphism and stenosis of the coronary artery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078625/
https://www.ncbi.nlm.nih.gov/pubmed/23563003
http://dx.doi.org/10.5144/0256-4947.2013.149
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