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Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis
BACKGROUND: Many studies have reported that the IL-1β + 3954C/T polymorphism (rs1143634) is related to myocardial infarction (MI). To classify the association between IL-1β + 3954C/T and MI susceptibility, we performed a meta-analysis. METHODS: We retrieved relevant literature from electronic databa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078675/ https://www.ncbi.nlm.nih.gov/pubmed/30045312 http://dx.doi.org/10.1097/MD.0000000000011645 |
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author | Fang, Yizhen Xie, Huabin Lin, Zhiyuan |
author_facet | Fang, Yizhen Xie, Huabin Lin, Zhiyuan |
author_sort | Fang, Yizhen |
collection | PubMed |
description | BACKGROUND: Many studies have reported that the IL-1β + 3954C/T polymorphism (rs1143634) is related to myocardial infarction (MI). To classify the association between IL-1β + 3954C/T and MI susceptibility, we performed a meta-analysis. METHODS: We retrieved relevant literature from electronic databases (Embase, PubMed, Cochrane, and Web of Science). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed effect model or a random effect model. Sensitivity analysis and publication bias results are also presented. RESULTS: Nine eligible studies (2299 controls and 2203 cases) were included. The pooled results showed a significant relationship between MI and IL-1β + 3954C/T in an allelic comparison (T vs C: OR = 1.13, 95% CI 1.02–1.25, I(2) = 0%, P(H) = .448) and in a dominant model (TC + TT vs CC: OR = 1.15, 95% CI 1.02–1.30, I(2) = 0%, P(H) = .880). Ethnic subgroup analysis showed similar results in Caucasian populations: an allelic comparison (T vs C: OR = 1.16, 95% CI 1.04–1.29, I(2) = 0%, P(H) = .701), homozygote model (TT vs CC: OR = 1.36, 95% CI 1.04–1.79, I(2) = 0%, P(H) = .673), and dominant model (TC + TT vs CC: OR = 1.17, 95% CI 1.02–1.33, I(2) = 0%, P(H) = .851). In addition, similar effects remained in subgroups analyses of high-quality studies and PCR-RFLP (restriction fragment length polymorphism) data. CONCLUSION: Our meta-analysis proved that IL-1β + 3954C/T is associated with MI susceptibility, especially among Caucasian populations. |
format | Online Article Text |
id | pubmed-6078675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-60786752018-08-13 Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis Fang, Yizhen Xie, Huabin Lin, Zhiyuan Medicine (Baltimore) Research Article BACKGROUND: Many studies have reported that the IL-1β + 3954C/T polymorphism (rs1143634) is related to myocardial infarction (MI). To classify the association between IL-1β + 3954C/T and MI susceptibility, we performed a meta-analysis. METHODS: We retrieved relevant literature from electronic databases (Embase, PubMed, Cochrane, and Web of Science). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed effect model or a random effect model. Sensitivity analysis and publication bias results are also presented. RESULTS: Nine eligible studies (2299 controls and 2203 cases) were included. The pooled results showed a significant relationship between MI and IL-1β + 3954C/T in an allelic comparison (T vs C: OR = 1.13, 95% CI 1.02–1.25, I(2) = 0%, P(H) = .448) and in a dominant model (TC + TT vs CC: OR = 1.15, 95% CI 1.02–1.30, I(2) = 0%, P(H) = .880). Ethnic subgroup analysis showed similar results in Caucasian populations: an allelic comparison (T vs C: OR = 1.16, 95% CI 1.04–1.29, I(2) = 0%, P(H) = .701), homozygote model (TT vs CC: OR = 1.36, 95% CI 1.04–1.79, I(2) = 0%, P(H) = .673), and dominant model (TC + TT vs CC: OR = 1.17, 95% CI 1.02–1.33, I(2) = 0%, P(H) = .851). In addition, similar effects remained in subgroups analyses of high-quality studies and PCR-RFLP (restriction fragment length polymorphism) data. CONCLUSION: Our meta-analysis proved that IL-1β + 3954C/T is associated with MI susceptibility, especially among Caucasian populations. Wolters Kluwer Health 2018-07-27 /pmc/articles/PMC6078675/ /pubmed/30045312 http://dx.doi.org/10.1097/MD.0000000000011645 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Research Article Fang, Yizhen Xie, Huabin Lin, Zhiyuan Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis |
title | Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis |
title_full | Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis |
title_fullStr | Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis |
title_full_unstemmed | Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis |
title_short | Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis |
title_sort | association between il-1β + 3954c/t polymorphism and myocardial infarction risk: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078675/ https://www.ncbi.nlm.nih.gov/pubmed/30045312 http://dx.doi.org/10.1097/MD.0000000000011645 |
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