Autoimmune hepatitis following influenza virus vaccination: Two case reports

RATIONALE: Although immunization could possibly cause autoimmune hepatitis (AIH), to date, no cases of AIH have been reported secondary to influenza virus vaccination. This paper describes 2 women who developed AIH after receiving influenza virus vaccination. PATIENT CONCERNS AND DIAGNOSES: Two wome...

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Detalles Bibliográficos
Autores principales: Sasaki, Tokio, Suzuki, Yuji, Ishida, Kazuyuki, Kakisaka, Keisuke, Abe, Hiroaki, Sugai, Tamotsu, Takikawa, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078681/
https://www.ncbi.nlm.nih.gov/pubmed/30045302
http://dx.doi.org/10.1097/MD.0000000000011621
Descripción
Sumario:RATIONALE: Although immunization could possibly cause autoimmune hepatitis (AIH), to date, no cases of AIH have been reported secondary to influenza virus vaccination. This paper describes 2 women who developed AIH after receiving influenza virus vaccination. PATIENT CONCERNS AND DIAGNOSES: Two women presented with elevation of liver enzymes after receiving influenza virus vaccination. Both patients were diagnosed with AIH using the International Autoimmune Hepatitis Group criteria. INTERVENTION AND OUTCOMES: Both patients were treated with prednisolone. After the initiation of prednisolone, serum aminotransferase levels were observed to return to the reference range in both patients. LESSONS: Influenza virus vaccination could trigger the development of AIH. Clinicians should be mindful of the fact that AIH can occur after influenza virus vaccination.

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