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Case report: narcolepsy type 1 in an adolescent with HIV infection—coincidence or potential trigger?
RATIONALE: Despite the acknowledged importance of environmental risk factors in the etiology of narcolepsy, there is little research on this topic. HIV as a trigger for narcolepsy has not been systematically investigated. PATIENT CONCERNS: We describe a case of narcolepsy type 1 (NT1) in an adolesce...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078734/ https://www.ncbi.nlm.nih.gov/pubmed/30045272 http://dx.doi.org/10.1097/MD.0000000000011490 |
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author | Scherrer, Karin Sofia Relly, Christa Hackenberg, Annette Berger, Christoph Paioni, Paolo |
author_facet | Scherrer, Karin Sofia Relly, Christa Hackenberg, Annette Berger, Christoph Paioni, Paolo |
author_sort | Scherrer, Karin Sofia |
collection | PubMed |
description | RATIONALE: Despite the acknowledged importance of environmental risk factors in the etiology of narcolepsy, there is little research on this topic. HIV as a trigger for narcolepsy has not been systematically investigated. PATIENT CONCERNS: We describe a case of narcolepsy type 1 (NT1) in an adolescent with HIV infection presenting with increased daytime sleepiness and excessive weight gain. DIAGNOSES: NT1 was diagnosed according to the criteria of the third edition of the International Classification of Sleep Disorders (ICSD-3). INTERVENTIONS: Pharmacological treatment with methylphenidate. OUTCOMES: Four months after initiation of methylphenidate therapy the increased daytime sleepiness improved and excessive weight gain stopped. LESSONS: Diagnosis of NT1 can be challenging at disease onset and is often delayed, especially in the pediatric population, because symptoms usually evolve gradually. The case presented here raises the possibility that the HIV infection may play a role in the pathogenesis of NT1 serving as trigger for autoimmune-mediated destruction of hypocretin-secreting neurons. |
format | Online Article Text |
id | pubmed-6078734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-60787342018-08-13 Case report: narcolepsy type 1 in an adolescent with HIV infection—coincidence or potential trigger? Scherrer, Karin Sofia Relly, Christa Hackenberg, Annette Berger, Christoph Paioni, Paolo Medicine (Baltimore) Research Article RATIONALE: Despite the acknowledged importance of environmental risk factors in the etiology of narcolepsy, there is little research on this topic. HIV as a trigger for narcolepsy has not been systematically investigated. PATIENT CONCERNS: We describe a case of narcolepsy type 1 (NT1) in an adolescent with HIV infection presenting with increased daytime sleepiness and excessive weight gain. DIAGNOSES: NT1 was diagnosed according to the criteria of the third edition of the International Classification of Sleep Disorders (ICSD-3). INTERVENTIONS: Pharmacological treatment with methylphenidate. OUTCOMES: Four months after initiation of methylphenidate therapy the increased daytime sleepiness improved and excessive weight gain stopped. LESSONS: Diagnosis of NT1 can be challenging at disease onset and is often delayed, especially in the pediatric population, because symptoms usually evolve gradually. The case presented here raises the possibility that the HIV infection may play a role in the pathogenesis of NT1 serving as trigger for autoimmune-mediated destruction of hypocretin-secreting neurons. Wolters Kluwer Health 2018-07-27 /pmc/articles/PMC6078734/ /pubmed/30045272 http://dx.doi.org/10.1097/MD.0000000000011490 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Scherrer, Karin Sofia Relly, Christa Hackenberg, Annette Berger, Christoph Paioni, Paolo Case report: narcolepsy type 1 in an adolescent with HIV infection—coincidence or potential trigger? |
title | Case report: narcolepsy type 1 in an adolescent with HIV infection—coincidence or potential trigger? |
title_full | Case report: narcolepsy type 1 in an adolescent with HIV infection—coincidence or potential trigger? |
title_fullStr | Case report: narcolepsy type 1 in an adolescent with HIV infection—coincidence or potential trigger? |
title_full_unstemmed | Case report: narcolepsy type 1 in an adolescent with HIV infection—coincidence or potential trigger? |
title_short | Case report: narcolepsy type 1 in an adolescent with HIV infection—coincidence or potential trigger? |
title_sort | case report: narcolepsy type 1 in an adolescent with hiv infection—coincidence or potential trigger? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078734/ https://www.ncbi.nlm.nih.gov/pubmed/30045272 http://dx.doi.org/10.1097/MD.0000000000011490 |
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