Bringing diffuse X-ray scattering into focus()

X-ray crystallography is experiencing a renaissance as a method for probing the protein conformational ensemble. The inherent limitations of Bragg analysis, however, which only reveals the mean structure, have given way to a surge in interest in diffuse scattering, which is caused by structure varia...

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Detalles Bibliográficos
Autores principales: Wall, Michael E, Wolff, Alexander M, Fraser, James S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078797/
https://www.ncbi.nlm.nih.gov/pubmed/29455056
http://dx.doi.org/10.1016/j.sbi.2018.01.009
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author Wall, Michael E
Wolff, Alexander M
Fraser, James S
author_facet Wall, Michael E
Wolff, Alexander M
Fraser, James S
author_sort Wall, Michael E
collection PubMed
description X-ray crystallography is experiencing a renaissance as a method for probing the protein conformational ensemble. The inherent limitations of Bragg analysis, however, which only reveals the mean structure, have given way to a surge in interest in diffuse scattering, which is caused by structure variations. Diffuse scattering is present in all macromolecular crystallography experiments. Recent studies are shedding light on the origins of diffuse scattering in protein crystallography, and provide clues for leveraging diffuse scattering to model protein motions with atomic detail.
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spelling pubmed-60787972018-08-06 Bringing diffuse X-ray scattering into focus() Wall, Michael E Wolff, Alexander M Fraser, James S Curr Opin Struct Biol Article X-ray crystallography is experiencing a renaissance as a method for probing the protein conformational ensemble. The inherent limitations of Bragg analysis, however, which only reveals the mean structure, have given way to a surge in interest in diffuse scattering, which is caused by structure variations. Diffuse scattering is present in all macromolecular crystallography experiments. Recent studies are shedding light on the origins of diffuse scattering in protein crystallography, and provide clues for leveraging diffuse scattering to model protein motions with atomic detail. 2018-02-16 2018-06 /pmc/articles/PMC6078797/ /pubmed/29455056 http://dx.doi.org/10.1016/j.sbi.2018.01.009 Text en http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wall, Michael E
Wolff, Alexander M
Fraser, James S
Bringing diffuse X-ray scattering into focus()
title Bringing diffuse X-ray scattering into focus()
title_full Bringing diffuse X-ray scattering into focus()
title_fullStr Bringing diffuse X-ray scattering into focus()
title_full_unstemmed Bringing diffuse X-ray scattering into focus()
title_short Bringing diffuse X-ray scattering into focus()
title_sort bringing diffuse x-ray scattering into focus()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078797/
https://www.ncbi.nlm.nih.gov/pubmed/29455056
http://dx.doi.org/10.1016/j.sbi.2018.01.009
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