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DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs
RNAi-based gene therapy using miRNA-adapted short hairpin RNAs (shRNA(miR)) is a powerful approach to modulate gene expression. However, we have observed low viral titers with shRNA(miR)-containing recombinant vectors and hypothesized that this could be due to cleavage of viral genomic RNA by the en...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078836/ https://www.ncbi.nlm.nih.gov/pubmed/30195795 http://dx.doi.org/10.1016/j.omtn.2018.07.002 |