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Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations

The capacity of differentiation of human pluripotent stem cells (hPSCs), which include both embryonic stem cells and induced pluripotent stem cells, into cardiomyocytes (CMs) in vitro provides an unlimited resource for human CMs for a wide range of applications such as cell based cardiac repair, car...

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Detalles Bibliográficos
Autores principales: Jiang, Yanqing, Park, Peter, Hong, Sang-Min, Ban, Kiwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078855/
https://www.ncbi.nlm.nih.gov/pubmed/29890820
http://dx.doi.org/10.14348/molcells.2018.0143
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author Jiang, Yanqing
Park, Peter
Hong, Sang-Min
Ban, Kiwon
author_facet Jiang, Yanqing
Park, Peter
Hong, Sang-Min
Ban, Kiwon
author_sort Jiang, Yanqing
collection PubMed
description The capacity of differentiation of human pluripotent stem cells (hPSCs), which include both embryonic stem cells and induced pluripotent stem cells, into cardiomyocytes (CMs) in vitro provides an unlimited resource for human CMs for a wide range of applications such as cell based cardiac repair, cardiac drug toxicology screening, and human cardiac disease modeling. However, their applicability is significantly limited by immature phenotypes. It has been well known that currently available CMs derived from hPSCs (hPSC-CMs) represent immature embryonic or fetal stage CMs and are functionally and structurally different from mature human CMs. To overcome this critical issue, several new approaches aiming to generate more mature hPSC-CMs have been developed. This review describes recent approaches to generate more mature hPSC-CMs including their scientific principles, advantages, and limitations.
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spelling pubmed-60788552018-08-23 Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations Jiang, Yanqing Park, Peter Hong, Sang-Min Ban, Kiwon Mol Cells Minireview The capacity of differentiation of human pluripotent stem cells (hPSCs), which include both embryonic stem cells and induced pluripotent stem cells, into cardiomyocytes (CMs) in vitro provides an unlimited resource for human CMs for a wide range of applications such as cell based cardiac repair, cardiac drug toxicology screening, and human cardiac disease modeling. However, their applicability is significantly limited by immature phenotypes. It has been well known that currently available CMs derived from hPSCs (hPSC-CMs) represent immature embryonic or fetal stage CMs and are functionally and structurally different from mature human CMs. To overcome this critical issue, several new approaches aiming to generate more mature hPSC-CMs have been developed. This review describes recent approaches to generate more mature hPSC-CMs including their scientific principles, advantages, and limitations. Korean Society for Molecular and Cellular Biology 2018-07-31 2018-06-12 /pmc/articles/PMC6078855/ /pubmed/29890820 http://dx.doi.org/10.14348/molcells.2018.0143 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
spellingShingle Minireview
Jiang, Yanqing
Park, Peter
Hong, Sang-Min
Ban, Kiwon
Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations
title Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations
title_full Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations
title_fullStr Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations
title_full_unstemmed Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations
title_short Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations
title_sort maturation of cardiomyocytes derived from human pluripotent stem cells: current strategies and limitations
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078855/
https://www.ncbi.nlm.nih.gov/pubmed/29890820
http://dx.doi.org/10.14348/molcells.2018.0143
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