A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways

The H2.0-like homeobox transcription factor (HLX) regulates hematopoietic differentiation and is overexpressed in Acute Myeloid Leukemia (AML), but the mechanisms underlying these functions remain unclear. We demonstrate here that HLX overexpression leads to a myeloid differentiation block both in z...

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Detalles Bibliográficos
Autores principales: Piragyte, Indre, Clapes, Thomas, Polyzou, Aikaterini, Klein Geltink, Ramon I., Lefkopoulos, Stylianos, Yin, Na, Cauchy, Pierre, Curtis, Jonathan D., Klaeylé, Lhéanna, Langa, Xavier, Beckmann, Cora C. A., Wlodarski, Marcin W., Müller, Patrick, Van Essen, Dominic, Rambold, Angelika, Kapp, Friedrich G., Mione, Marina, Buescher, Joerg M., Pearce, Erika L., Polyzos, Alexander, Trompouki, Eirini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078963/
https://www.ncbi.nlm.nih.gov/pubmed/30082823
http://dx.doi.org/10.1038/s41467-018-05311-4

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